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MILLIPLEX®小鼠血管生成/生长因子磁珠组套 - 癌症多重检测试剂盒

Configurable Mouse Angiogenesis/Growth Factor 27-Plex Panel 1

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关于此项目

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

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产品名称

MILLIPLEX®小鼠血管生成/生长因子磁珠组套 - 癌症多重检测试剂盒, Configurable Mouse Angiogenesis/Growth Factor 27-Plex Panel 1

species reactivity

mouse

manufacturer/tradename

Milliplex®

Quality Level

200

packaging

1 ea of

assay range

accuracy: 90-104%
standard curve range: 1-1,000 pg/mL
(Endothelin-1)
standard curve range: 137-100,000 pg/mL
(Follistatin)
standard curve range: 137-100,000 pg/mL
(HGF)
standard curve range: 137-100,000 pg/mL
(SDF-1)
standard curve range: 14-10,000 pg/mL
(IL-1b)
standard curve range: 14-10,000 pg/mL
(Leptin)
standard curve range: 14-10,000 pg/mL
(MIP-1α)
standard curve range: 14-10,000 pg/mL
(sALK-1)
standard curve range: 14-10,000 pg/mL
(sCD31/ PECAM-1)
standard curve range: 27-20,000 pg/mL
(Angiopoietin-2)
standard curve range: 27-20,000 pg/mL
(EGF)
standard curve range: 27-20,000 pg/mL
(Endoglin)
standard curve range: 27-20,000 pg/mL
(MCP-1)
standard curve range: 27-20,000 pg/mL
(VEGF-C)
standard curve range: 3-2,000 pg/mL
(PLGF-2)
standard curve range: 6-4,000 pg/mL
(TNFα)
standard curve range: 6-4,000 pg/mL
(VEGF-A)
standard curve range: 69-50,000 pg/mL
(FGF-2/FGF-basic)
standard curve range: 69-50,000 pg/mL
(Prolactin)
standard curve range: 69-50,000 pg/mL
(VEGF-D)
standard curve range: 69-50,000 pg/mL
(sFasL)
standard curve range: 7-5,000 pg/mL
(Amphiregulin)
standard curve range: 7-5,000 pg/mL
(Betacellulin)
standard curve range: 7-5,000 pg/mL
(G-CSF)
standard curve range: 7-5,000 pg/mL
(IL-17A)
standard curve range: 7-5,000 pg/mL
(IL-6)
standard curve range: 7-5,000 pg/mL
(KC/CXCL1)

technique(s)

multiplexing: suitable

input

cell culture supernatant(s)

detection method

fluorometric (Luminex xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Other Notes

灵敏度：有关单个分析物的灵敏度，请参阅试剂盒方案。

Legal Information

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 27 analytes in mouse serum, plasma, cell culture supernatants, and cell/tissue extracts.

Analytes included: sALK-1, Amphiregulin, Angiopoietin-2, Betacellulin, sCD31/sPECAM-1, EGF, Endoglin, Endothelin-1, sFasL, FGF-2 (FGF-basic), Follistatin (FST), G-CSF, HGF, IL-1β, IL-6, IL-17A (CTLA8), KC (GRO/CINC-1/CXCL1), Leptin, MCP-1 (CCL2), MIP-1α (CCL3), Placental Growth Factor 2 (PLGF-2), Prolactin, SDF-1 (CXCL12), TNF-α, VEGF-A, VEGF-C, VEGF-D Note: Sample type must be selected when configuring this kit. Angiopeoitin-2, Betacellulin, and PECAM-1 should not be run in serum/plasma samples.

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

Multiplex Capability: Simultaneous quantification of up to 24 analytes in serum/plasma or 27 analytes in cell culture samples, including key angiogenesis and growth factors such as VEGF-A, TNFα, IL-6, FGF-2, and more.

Wide Dynamic Range: Standard curve ranges vary by analyte, covering low to high pg/mL concentrations.

Flexible Sample Types: Compatible with mouse serum, plasma, tissue/cell culture supernatants or lysates.

Supports Studies on Tumor Microenvironment: Helps investigate how hypoxia, inflammation, and cytokine signaling contribute to abnormal vascularization in tumors.

Supports Translational Research: Enables biomarker discovery in mouse models that mimic human disease, supporting translational studies in oncology, inflammation, and vascular biology.

General description

Angiogenesis, the development of new vascular networks, is a key process in normal growth and development as well as in wound healing, with homeostasis maintained by a delicate balance of angiogenic factors and inhibitors. Consequently, insufficient, or excessive blood vessel growth underlies many diseases, including cardiovascular disease, diabetic ulcers, macular degeneration, and cancer. Angiogenesis plays a significant role in tumor growth and metastasis.

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

存储类别

10 - Combustible liquids

wgk

WGK 3

法规信息

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Aziza R Alrafiah
Biomedicines, 9(9) (2021-09-29)
The present study focused on secondary injury following the middle cerebral artery (MCA) occlusion in rats not linked to the MCA's feeding zone. This entity has been very rarely studied. Additionally, this study investigated the rates of expression of five
Sara Luscieti et al.
Blood, 130(17), 1934-1945 (2017-08-05)
Cellular iron homeostasis is controlled by the iron regulatory proteins (IRPs) 1 and 2 that bind cis-regulatory iron-responsive elements (IRE) on target messenger RNAs (mRNA). We identified profilin 2 (Pfn2) mRNA, which encodes an actin-binding protein involved in endocytosis and
Pier-Anne Lachance et al.
PloS one, 8(9), e76078-e76078 (2013-10-03)
During acute inflammation, functioning lymphatics are believed to reduce edema and to provide a transiting route for immune cells, but the extent at which the dermal lymphatic remodeling impacts lymphatic transport or the factors regulating these changes remains unclear. Herein
Wenjie Li et al.
Stem cells international, 2022, 8540535-8540535 (2022-06-18)
Adipose-derived stem cells (ASCs) improve the self-renewal and survival of fat grafts in breast reconstruction after oncology surgery. However, ASCs have also been found to enhance breast cancer growth, and its role in tumor proliferation remains largely elusive. Here, we
Sneha Sundaram et al.
Anticancer research, 39(4), 1729-1738 (2019-04-07)
Monocyte chemotactic protein-1 (MCP1) is a potent adipokine. This study tested the hypothesis that adipose-produced MCP1 contributes to metastasis. In a spontaneous metastasis model of Lewis lung carcinoma (LLC), male adipose MCP1-deficient (Mcp1-/-) and wild-type (WT) mice were fed the
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