MABT372
抗-Mastl抗体（克隆 4F9）
clone 4F9, from mouse
别名:
Serine/threonine-protein kinase greatwall, GW, GWL, hGWL, Microtubule-associated serine/threonine-protein kinase-like, MAST-L
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
4F9, monoclonal
Application:
IHC, WB
Citations:
7
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
4F9, monoclonal
species reactivity
human
technique(s)
immunohistochemistry: suitable, western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MASTL(84930)
General description
Mastl也称丝氨酸/苏氨酸-蛋白激酶长城（GW）和微管相关丝氨酸/苏氨酸-蛋白激酶（MAST-L）。 Mastl 是一种丝氨酸/苏氨酸激酶，通过蛋白磷酸酶2A（PP2A）的失活，调节M 期有丝分裂的进入和维持。Mastl 也被认为参与巨核细胞分化和血小板减少症2（THC2）的调节。
观测值〜97 kDa。某些裂解液可能会出现未表征的条带。
Immunogen
对应于人Mastl的C末端的重组蛋白。
表位：C端
Application
使用经验证可用于蛋白质印迹和&IHC的该小鼠单克隆抗-Mastl 1抗体（克隆4F9）检测Mastl 。
免疫组化分析：一个代表性批次的 1：50-2,000 稀释液在人前列腺癌和人睾丸组织切片中检测到Mastl 。
研究子类别
粘附（CAMs）
粘附（CAMs）
研究类别
细胞结构
细胞结构
Physical form
形式：纯化
纯化的小鼠单克隆IgG1κ，溶于含0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl和0.05％叠氮化钠的缓冲液中。
蛋白G纯化
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
Analysis Note
通过蛋白质印迹对人口腔鳞状细胞癌裂解物进行了评估。
蛋白质印迹分析：1.0 µg/mL该抗体在10 µg 人口腔鳞状细胞癌裂解物中检测到Mastl。
蛋白质印迹分析：1.0 µg/mL该抗体在10 µg 人口腔鳞状细胞癌裂解物中检测到Mastl。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Odjo G Gouttia et al.
Frontiers in cell and developmental biology, 10, 904719-904719 (2022-10-18)
Platinum-based chemotherapy is the standard first-line treatment for oral squamous cell carcinoma (OSCC) that is inoperable, recurrent, or metastatic. Platinum sensitivity is a major determinant of patient survival in advanced OSCC. Here, we investigated the involvement of MASTL, a cell
Srijayaprakash Babu Uppada et al.
Molecular cancer, 17(1), 111-111 (2018-08-03)
Chemotherapeutic agents that modulate cell cycle checkpoints and/or tumor-specific pathways have shown immense promise in preclinical and clinical studies aimed at anti-cancer therapy. MASTL (Greatwall in Xenopus and Drosophila), a serine/threonine kinase controls the final G2/M checkpoint and prevents premature
Dario Hermida et al.
Molecular & cellular proteomics : MCP, 19(2), 326-343 (2019-12-20)
The human MASTL (Microtubule-associated serine/threonine kinase-like) gene encodes an essential protein in the cell cycle. MASTL is a key factor preventing early dephosphorylation of M-phase targets of Cdk1/CycB. Little is known about the mechanism of MASTL activation and regulation. MASTL
Yanqiu Li et al.
eLife, 12 (2023-09-06)
Checkpoint activation after DNA damage causes a transient cell cycle arrest by suppressing cyclin-dependent kinases (CDKs). However, it remains largely elusive how cell cycle recovery is initiated after DNA damage. In this study, we discovered the upregulated protein level of
Brittiny Dhital et al.
Cell reports. Medicine, 4(2), 100937-100937 (2023-02-15)
Metastatic prostate cancer (PCa) inevitably acquires resistance to standard therapy preceding lethality. Here, we unveil a chromosomal instability (CIN) tolerance mechanism as a therapeutic vulnerability of therapy-refractory lethal PCa. Through genomic and transcriptomic analysis of patient datasets, we find that
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