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生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
9D2.1, monoclonal
种属反应性
human, mouse
技术
immunohistochemistry: suitable
western blot: suitable
同位素/亚型
IgMκ
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... LIMS1(3987)
一般描述
Pinch-1 (Particularly interesting new Cys-His protein 1) is also known as LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1). Pinch-1 is expressed in most tissues except for brain. Pinch-1 is an adhesion protein and is part of the ILK-PINCH complex that is involved in integrin and growth factor signaling by coupling surface receptors to downstream signaling molecules related to the regulation of cell survival, cell proliferation and cell differentiation.
免疫原
KLH-conjugated linear peptide corresponding to human Pinch-1.
应用
Anti-Pinch-1 Antibody, clone 9D2.1 is a highly specific mouse monoclonal antibody, that targets Pinch-1 & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Pinch-1 in human renal tubules and mouse renal tubules tissue.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Adhesion (CAMs)
Adhesion (CAMs)
质量
Evaluated by Western Blotting in human heart tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Pinch-1 in 10 µg of human heart tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Pinch-1 in 10 µg of human heart tissue lysate.
目标描述
~40 kDa observed. Uniprot describes 4 isoforms produced by alternative splicing at ~38 kDa, ~44 kDa, ~37 kDa, and ~42 kDa
外形
Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
Human heart tissue lysate
Human heart tissue lysate
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Georgios Tsinias et al.
Analytical cellular pathology (Amsterdam), 2018, 2989635-2989635 (2018-05-15)
Focal adhesion signaling to actin cytoskeleton is critically implicated in cell migration and cancer invasion and metastasis. Actin-binding proteins cofilin and N-WASP regulate actin filament turnover, and focal adhesion proteins parvins and PINCH mediate integrin signaling to the actin cytoskeleton.
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