产品名称
抗胰岛素受体抗体（β亚基，克隆CT-3）, clone CT-3, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
CT-3, monoclonal
species reactivity
mouse, rat (demonstrated by independent lab), human
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... INSR(3643)
mouse ... Insr(16337)
rat ... Insr(24954)
Analysis Note
对照
小鼠脑组织裂解液
小鼠脑组织裂解液
通过蛋白质印迹法在小鼠脑组织裂解物中进行评价。
蛋白质印迹分析：0.5 µg/mL 的该抗体在 10 µg 小鼠脑组织裂解物中检测到胰岛素受体β亚基。
蛋白质印迹分析：0.5 µg/mL 的该抗体在 10 µg 小鼠脑组织裂解物中检测到胰岛素受体β亚基。
Application
使用该经验证可用于WB、IH的该抗胰岛素受体抗体（β亚基，克隆CT-3）检测胰岛素受体。
研究子类别
胰岛素/能量信号
胰岛素/能量信号
研究类别
代谢
代谢
Biochem/physiol Actions
该抗体识别人胰岛素受体β亚基的C末端。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
95kda
胰岛素受体是一种酪氨酸激酶受体，结合胰岛素时，启动多条信号转导通路，包括JNK、PI 3-激酶、Akt 和PKC。研究人员对于将这些胰岛素R依赖性通路的药物干预用于治疗胰岛素抵抗、肥胖和糖尿病有极大的兴趣。胰岛素受体（IR）被合成为单一多肽，该多肽随后裂解生成二硫键连接的一条胞外α链和一条跨膜胞内β链。β链具有多个酪氨酸磷酸化位点，包括激活环（activation loop）上的三个自磷酸化位点。IR 总体结构与IGF-I 受体高度同源，只是C末端的两个蛋白有些差异。 IR 信号主要通过胰岛素受体基质（IRS）蛋白质家族的磷酸化进行，该蛋白为含蛋白SHA结构域创造停泊位点（docking site）。胰岛素信号传导高度依赖于PI3 激酶通路和 Akt通路，Akt通路似乎介导胰岛素的功能。
Immunogen
对应于人胰岛素受体β亚基的C末端的重组蛋白。
表位：C端
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
纯化的小鼠单克隆IgG1κ溶于含0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl和0.05％叠氮化钠的缓冲液中。
蛋白G纯化
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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