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Merck
CN

MABS487

抗-修饰瓜氨酸抗体，克隆C4

clone C4, from human(Recombinant)

别名:

citrulline, modified citrulline

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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产品名称

抗-修饰瓜氨酸抗体，克隆C4, clone C4, from human(Recombinant)

biological source

human (Recombinant)

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

C4, monoclonal

species reactivity (predicted by homology)

all

technique(s)

ELISA: suitable
western blot: suitable

isotype

IgG1λ

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

相关类别

Analysis Note

通过蛋白质印迹法在处理的角质化人细胞裂解物中进行评价。

蛋白质印迹分析：该抗体以1:1,000稀释度使用抗人二抗在10 µg处理的人角质化细胞裂解物中检测到修饰的瓜氨酸。

Application

研究子类别
信号神经科学
研究类别
信号传导
蛋白质印迹分析：一个代表性批次以1:1,000稀释度使用抗人二抗在10 µg处理的HL-60细胞裂解物中检测到修饰的瓜氨酸。
ELISA分析：一个代表性批次在ELISA中检测到了修饰的瓜氨酸。
这种抗修饰瓜氨酸抗体经验证可用于蛋白质印迹法和ELISA检测修饰瓜氨酸。

Disclaimer

除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。

General description

瓜氨酸被认为是一种未结合的氨基酸，在中间代谢中起作用。它是由肠上皮细胞在小肠中产生的。血浆和血清中的瓜氨酸浓度被认为是疾病期间小肠功能和小肠质量可靠且无创的生物标志物。瓜氨酸也被证明在蛋白质稳态中起着重要作用。改性瓜氨酸是瓜氨酸的化学改性形式，具有更高的免疫原性。

Immunogen

经2,3-丁二酮单肟和安替比林修饰的含瓜氨酸的肽。

Other Notes

浓度：请参考特定批次的数据表。

Physical form

人重组单克隆IgG1λ，溶于含0.05%叠氮化钠PBS的缓冲液中。
形式：纯化
纯化蛋白A

Preparation Note

自接收之日起，在2-8°C下可稳定保存1年。

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存储类别

10 - Combustible liquids

wgk

WGK 2

分析证书(COA)

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Katerina D Samara et al.
Respiratory research, 18(1), 218-218 (2017-12-31)
Increased protein citrullination and peptidylarginine deiminases (PADIs), which catalyze the citrullination process, are central in Rheumatoid arthritis pathogenesis and probably involved in the initial steps towards autoimmunity. Approximately, 10% of RA patients develop clinically significantly ILD. A possible shared role
Issa O Yusuf et al.
Neurobiology of disease, 192, 106414-106414 (2024-01-23)
Alteration in protein citrullination (PC), a common posttranslational modification (PTM), contributes to pathogenesis in various inflammatory disorders. We previously reported that PC and protein arginine deiminase 2 (PAD2), the predominant enzyme isoform that catalyzes this PTM in the central nervous
Association of citrullination with the progression of aortic stenosis.
Kim, et al.
Scientific Reports, 13, 8919-8919 (2023)
Seema Qamar et al.
Cell, 173(3), 720-734 (2018-04-21)
Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the intrinsically disordered low-complexity (LC) domain of FUS. Here, we report that cooperative cation-π interactions between tyrosines in the
Melissa M Ledet et al.
BMC cancer, 18(1), 412-412 (2018-04-14)
Mammary cancer is highly prevalent in dogs and cats and results in a poor prognosis due to critically lacking viable treatment options. Recent human and mouse studies have suggested that inhibiting peptidyl arginine deiminase enzymes (PAD) may be a novel
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