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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
CPTC-ODC1-2, monoclonal
Application:
western blot
Species reactivity:
human
Citations:
3
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
抗-ODC1抗体,克隆CPTC-ODC1-2, clone CPTC-ODC1-2, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
CPTC-ODC1-2, monoclonal
species reactivity
human
technique(s)
western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ODC1(4953)
Analysis Note
对照
MCF-7细胞裂解物
MCF-7细胞裂解物
通过蛋白质印迹法在MCF-7细胞裂解物中进行评估。
蛋白质印迹分析:10 µg/mL的该抗体在10 µg MCF-7细胞裂解物中检测到ODC1。
蛋白质印迹分析:10 µg/mL的该抗体在10 µg MCF-7细胞裂解物中检测到ODC1。
Application
研究类别
信号传导
信号传导
经验证,该抗ODC1抗体克隆CPTC-ODC1-2可用于WB中检测ODC1。
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明,否则我们的产品预期仅用于研究用途,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
General description
观测分子量〜51 kDa。 在某些裂解物中可能观察到约100 kDa的条带,可能是该蛋白的同型二聚体。
鸟氨酸脱羧酶(ODC1)是多胺合成中的第一个酶,是正常生长所必需的,并且在许多类型的癌症中都会增加。已显示ODC1抑制酵母中fmc1的缺失并恢复健康的呼吸生长。ODC1可能在促进肝细胞DNA合成中发挥作用。
Immunogen
对应于人ODC1的全长重组蛋白。
从美国国家癌症研究’所癌症临床蛋白质组学技术(CPTC)计划获得的材料。
从美国国家癌症研究’所癌症临床蛋白质组学技术(CPTC)计划获得的材料。
Other Notes
浓度:关于批次特定浓度请参见检验报告。
Physical form
形式:纯化
纯化的小鼠单克隆IgG2aκ,溶于含0.1 M Tris-甘氨酸(pH 7.4)、150 mM NaCl和0.05%叠氮化钠的缓冲液中。
蛋白G
Preparation Note
自接收之日起,在2-8°C下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Renee C Geck et al.
The Journal of biological chemistry, 295(19), 6263-6277 (2020-03-07)
Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens.
Guillaume N Fiches et al.
PLoS pathogens, 18(4), e1010503-e1010503 (2022-04-30)
Polyamines are critical metabolites involved in various cellular processes and often dysregulated in cancers. Kaposi's sarcoma-associated Herpesvirus (KSHV), a defined human oncogenic virus, leads to profound alterations of host metabolic landscape to favor development of KSHV-associated malignancies. In our studies
Milind D Chalishazar et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(16), 5107-5121 (2019-06-06)
Small-cell lung cancer (SCLC) has been treated clinically as a homogeneous disease, but recent discoveries suggest that SCLC is heterogeneous. Whether metabolic differences exist among SCLC subtypes is largely unexplored. In this study, we aimed to determine whether metabolic vulnerabilities
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