MABS1703
Anti-MGAT2 Antibody, clone 4A5.2
clone 4A5.2, from mouse
别名:
Alpha-1, 6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, Beta-1, 2-N-acetylglucosaminyltransferase II, GlcNAc-T II, GNT-II, Mannoside acetylglucosaminyltransferase 2, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase
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About This Item
生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
4A5.2, monoclonal
种属反应性
human
技术
western blot: suitable
同位素/亚型
IgG2aκ
NCBI登记号
UniProt登记号
运输
ambient
靶向翻译后修饰
glycosylation
基因信息
human ... MOGAT2(80168)
一般描述
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143; UniProt Q10469; also known as Beta-1,2-N-acetylglucosaminyltransferase II, GlcNAc-T II, GNT-II, Mannoside acetylglucosaminyltransferase 2, MGAT2, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyl-transferase II) is encoded by the MGAT2 (also known as CDG2A) gene (Gene ID 4247) in human. MGAT2 is a Golgi enzyme that catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans. It possesses the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. It is highly expressed in small intestine in mice and humans. Mutations in MGTA2 gene are known to cause congenital disorders of glycosylation 2A, which is a multi-system disorder caused by defective glycoprotein biosynthesis. It leads to under-glycosylated levels of serum glycoproteins that result in defects in neuronal development, coagulation disorders, hypotonia, and immunodeficiency.
Ref.:
Tan, J., et al. (1995). Eur. J. Biochem. 231, 317-328.
Tan J., et al. (1996), Am. J. Hum. Genet. 159, 810-817.
Ref.:
Tan, J., et al. (1995). Eur. J. Biochem. 231, 317-328.
Tan J., et al. (1996), Am. J. Hum. Genet. 159, 810-817.
特异性
Clone 4A5.2 targets an internal epitope within the C-terminal half of human MGAT2.
免疫原
GST-tagged internal fragment from the C-terminal half of human MGAT2.
应用
Detect MGAT2 using this mouse monoclonal Anti-MGAT2 Antibody, clone 4A5.2, Cat. No. MABS1703, validated for use in Western Blotting.
Research Category
Signaling
Signaling
质量
Evaluated by Western Blotting in T47D cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected MGAT2 in 10 µg of T47D cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected MGAT2 in 10 µg of T47D cell lysate.
目标描述
~52 kDa observed. 51.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
外形
Protein G purified.
Format: Purified
Purified mouse IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
其他说明
Concentration: Please refer to lot specific datasheet.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
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