推荐产品
生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
DB9, monoclonal
种属反应性
human
技术
immunohistochemistry: suitable
western blot: suitable
同位素/亚型
IgG1κ
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... TARDBP(23435)
一般描述
TAR DNA-binding protein 43 (TDP-43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson′s disease and Alzheimer′s disease.
免疫原
The antibody was raised against an immunogen consisting of His-tagged recombinant protein corresponding to amino acid residues 208-414 of human TDP-43.
应用
Detect TDP-43 using this Anti-TDP-43 Antibody, clone DB9 validated for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TDP-43 in human cerebellum, pancreas, and thalamus tissues.
质量
Evaluated by Western Blotting in SH-SY-5Y cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected TDP-43 in 10 µg of SH-SY-5Y cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected TDP-43 in 10 µg of SH-SY-5Y cell lysate.
目标描述
~43 kDa observed
外形
Format: Purified
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Silvia Silva-Hucha et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 21(3), e00340-e00340 (2024-03-13)
Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease characterized by severe muscle weakness mainly due to degeneration and death of motor neurons. A peculiarity of the neurodegenerative processes is the variable susceptibility among distinct neuronal populations, exemplified by the
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门