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Merck
CN
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文件

MABN774

Sigma-Aldrich

Anti-TDP-43 Antibody, clone DB9

clone DB9, from mouse

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别名:
TAR DNA-binding protein 43, TDP-43, TDP43, TAR DNA binding protein-43
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

mouse

质量水平

100

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

DB9, monoclonal

种属反应性

human

技术

immunohistochemistry: suitable
western blot: suitable

同位素/亚型

IgG1κ

NCBI登记号

NP_031401

UniProt登记号

Q13148

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... TARDBP(23435)

一般描述

TAR DNA-binding protein 43 (TDP-43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson′s disease and Alzheimer′s disease.

免疫原

The antibody was raised against an immunogen consisting of His-tagged recombinant protein corresponding to amino acid residues 208-414 of human TDP-43.

应用

Detect TDP-43 using this Anti-TDP-43 Antibody, clone DB9 validated for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TDP-43 in human cerebellum, pancreas, and thalamus tissues.

质量

Evaluated by Western Blotting in SH-SY-5Y cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected TDP-43 in 10 µg of SH-SY-5Y cell lysate.

目标描述

~43 kDa observed

外形

Format: Purified

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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