MABN69
抗-Caspr抗体（克隆K65/35）
clone K65/35, from mouse
别名:
contactin associated protein 1, neurexin 4, neurexin-4, contactin-associated protein 1, Neurexin IV, Neurexin-4
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
K65/35, monoclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
rat
Citations:
15
Technique(s):
immunohistochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-Caspr抗体（克隆K65/35）, clone K65/35, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
K65/35, monoclonal
species reactivity
rat
species reactivity (predicted by homology)
mouse (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
rat ... Cntnap1(84008)
Analysis Note
对照
大鼠脑膜组织裂解物
大鼠脑膜组织裂解物
通过蛋白质印迹在大鼠脑膜组织裂解物中进行了评估。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg大鼠脑膜组织裂解物中检测到Caspr。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg大鼠脑膜组织裂解物中检测到Caspr。
Application
免疫组化分析：一个先前批次的 1：300 稀释液在大鼠小脑和大鼠海马体组织中检测到 Caspr。
抗-Caspr抗体（克隆K65/35）是用于IH & WB的针对Caspr的抗体。
研究子类别
信号神经科学
信号神经科学
研究类别
神经科学
神经科学
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
接触蛋白相关蛋白1（Caspr）是一种单次跨膜I 型膜蛋白，属于轴突蛋白家族，包含一个F5/8 C型结构域、一个纤维蛋白原C末端结构域、两个EGF样结构域和四个层粘连蛋白样结构域。Caspr 与接触蛋白的相互作用已得到充分证明，这种相互作用对于Caspr 向质膜的运输、神经胶质细胞的髓鞘形成以及轴突-神经胶质连接的生成至关重要。研究也提示，Caspr可能在接触蛋白的细胞表面表达，及其对不同轴突结构域的靶向中起调节作用。Caspr的表达大多见于脑，主要见于副结轴突神经胶质连接（paranodal axoglial junction）中的CNS有髓神经纤维（myelinated nerve fiber）。
观测分子量~220 kDa
Immunogen
对应于大鼠Caspr的重组蛋白。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
纯化的小鼠单克隆IgG1κ，溶于含0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl和0.05％叠氮化钠的缓冲液中。
蛋白G
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Annika Balraj et al.
Developmental neurobiology, 82(4), 308-325 (2022-04-12)
Retinal ganglion cells generate a pattern of action potentials to communicate visual information from the retina to cortical areas. Myelin, an insulating sheath, wraps axonal segments to facilitate signal propagation and when deficient, can impair visual function. Optic nerve development
Jacob C A Edvinsson et al.
The journal of headache and pain, 23(1), 26-26 (2022-02-19)
5-Hydroxytryptamine (5-HT) receptors 1B, 1D and 1F have key roles in migraine pharmacotherapy. Selective agonists targeting these receptors, such as triptans and ditans, are effective in aborting acute migraine attacks and inhibit the in vivo release of calcitonin gene-related peptide
Anirban Paul et al.
Cell, 171(3), 522-539 (2017-09-26)
Understanding the organizational logic of neural circuits requires deciphering the biological basis of neuronal diversity and identity, but there is no consensus on how neuron types should be defined. We analyzed single-cell transcriptomes of a set of anatomically and physiologically characterized
Aida Maddahi et al.
The journal of headache and pain, 23(1), 152-152 (2022-12-02)
Hypothalamus is a key region in migraine attacks. In addition, women are disproportionately affected by migraine. The calcitonin gene-related peptide (CGRP) system is an important key player in migraine pathophysiology. CGRP signaling could be a target of hormones that influence
Hirosato Kanda et al.
Neuron, 104(5), 960-971 (2019-10-22)
Rapid conduction of nerve impulses is critical in life and relies on action potential (AP) leaps through the nodes of Ranvier (NRs) along myelinated nerves. While NRs are the only sites where APs can be regenerated during nerve conduction on
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