Anti-Neurexin-1-Beta Antibody

Neurexin-1-beta or Neurexin I-beta is a neuronal cell surface protein thought to be involved in cell recognition and cell adhesion through the formation of intracellular junctions via binding to neuroligins. Neurexin-1-beta may also have roles in the formation and maintenance of synaptic junctions, mediation of intracellular signaling, and angiogenesis.

This antibody recognizes the N-terminus within the extracellular domain of Neurexin-1-beta. This antibody does not cross-react with Neurexin1-alpha or Neurexin-2 (Prof. J. Trimmer, University of California, Davis.).

Epitope: N-terminus within the extracellular domain

Linear peptide corresponding to the N-terminus of human Neurexin-1-beta.

Anti-Neurexin-1-Beta Antibody is a highly specific mouse monoclonal antibody, that targets Neurexin 1 & has been tested in IHC.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Neurexin-1-beta in human cerebellum, rat frontal lobe, and human thalamus tissues.

Western Blotting Analysis: A representative lot detected Neurexin-1-beta in COS cell lysates transiently transfected with Flag-tagged Neurexin-1-beta, and demonstrated a loss of signal in COS cell lysates transiently transfected with Flag-tagged Neurexin-1-alpha or untagged Kv2.1 plasmids (Prof. J. Trimmer, University of California, Davis.).

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Evaluated by Immunohistochemistry in rat olfactory bulb tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Neurexin-1-beta in rat olfactory bulb tissue.

47 kDa calculated. This protein has been observed at ~70 kDa (Prof. J. Trimmer, University of California, Davis.). Uncharacterized band(s) may be observed in some cell lysates.

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Rat olfactory bulb tissue

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.