MABN50A4
抗-Olig2抗体，克隆211F1.1，Alexa Fluor™488结合物｜MABN50A4
clone 211F1.1, from mouse, ALEXA FLUOR™ 488
别名:
Oligodendrocyte transcription factor 2, Oligo2, Class B basic helix-loop-helix protein 1, bHLHb1, Class E basic helix-loop-helix protein 19, bHLHe19, Protein kinase C-binding protein 2, Protein kinase C-binding protein RACK17
产品名称
抗-Olig2抗体，克隆211F1.1，Alexa Fluor™488结合物｜MABN50A4, clone 211F1.1, from mouse, ALEXA FLUOR™ 488
biological source
mouse
conjugate
ALEXA FLUOR™ 488
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
211F1.1, monoclonal
species reactivity
rat, mouse
species reactivity (predicted by homology)
human (based on 100% sequence homology)
technique(s)
immunocytochemistry: suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... OLIG2(10215)
Analysis Note
对照
大鼠少突胶质前体细胞
大鼠少突胶质前体细胞
通过免疫细胞化学在大鼠少突胶质前体细胞中进行评估。
免疫细胞化学分析：该抗体以1:100稀释度在大鼠少突胶质前体细胞中检测到Olig2。
免疫细胞化学分析：该抗体以1:100稀释度在大鼠少突胶质前体细胞中检测到Olig2。
Application
研究子类别
发育神经科学
发育神经科学
研究类别
神经科学
神经科学
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
General description
少突胶质细胞谱系转录因子2（Olig2）是属于碱性螺旋-环-螺旋转录因子（bHLH）OLIG家族A组的蛋白质。bHLH蛋白分为6组（A-F），并通过其生化特性和结构进行表征。Olig2由于具有与其他bHLH蛋白形成异二聚体并与E盒结合的能力而被分类为A组。Olig2在发育过程中在确定运动神经元和少突胶质细胞在脊髓中的最终位置以及体细胞运动神经元在后脑内的发育中起着至关重要的作用。在少突胶质细胞和发育中的星形胶质细胞中观察到Olig2表达。最近的研究表明，Olig2在人少突胶质细胞瘤、中枢神经系统内的原发性肿瘤中高表达，在星形细胞瘤中呈中等表达。这些观察结果使得Olig2可能具有作为少突胶质细胞瘤诊断标志物的潜力。
未偶联的亲本抗体（目录号MABN50）的分子量约为37 kDa
Immunogen
对应于人Olig2的重组蛋白。
Physical form
纯化的小鼠单克隆IgG2a与Alexa Fluor™ 488偶联，溶于含0.1%叠氮化钠和15 mg/mL BSA的PBS中。
纯化蛋白G
Preparation Note
自接收之日起，以未稀释的等分试样在2-8°C下避光保存长达6个月。
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Sofía Puvogel et al.
Molecular psychiatry (2022-10-04)
The midbrain is an extensively studied brain region in schizophrenia, in view of its reported dopamine pathophysiology and neuroimmune changes associated with this disease. Besides the dopaminergic system, the midbrain contains other cell types that may be involved in schizophrenia
Itzy E Morales Pantoja et al.
PloS one, 15(6), e0233980-e0233980 (2020-06-09)
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS) that results in variable severities of neurodegeneration. The understanding of MS has been limited by the inaccessibility of the affected cells and the lengthy timeframe
Pavel Katsel et al.
NPJ schizophrenia, 5(1), 3-3 (2019-01-31)
Oligodendrocyte (OLG)-related abnormalities have been broadly observed in schizophrenia (SZ); however, the etiology of these abnormalities remains unknown. As SZ is broadly believed to be a developmental disorder, the etiology of the myelin abnormalities in SZ may be related to
Emma Gerrits et al.
Acta neuropathologica, 141(5), 681-696 (2021-02-21)
Alzheimer's disease (AD) is the most prevalent form of dementia and is characterized by abnormal extracellular aggregates of amyloid-β and intraneuronal hyperphosphorylated tau tangles and neuropil threads. Microglia, the tissue-resident macrophages of the central nervous system (CNS), are important for
Andy P Tsai et al.
Immunity, 56(9), 2121-2136 (2023-09-03)
Genetic association studies have demonstrated the critical involvement of the microglial immune response in Alzheimer's disease (AD) pathogenesis. Phospholipase C-gamma-2 (PLCG2) is selectively expressed by microglia and functions in many immune receptor signaling pathways. In AD, PLCG2 is induced uniquely
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