MABN495
抗-Aldh1L1抗体，克隆N103/39
clone N103/39, from mouse
别名:
Cytosolic 10-formyltetrahydrofolate dehydrogenase, 10-FTHFDH, FDH, Aldehyde dehydrogenase family 1 member L1
FBP-CI
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
N103/39, monoclonal
Application:
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
human, rat, mouse
Citations:
21
Technique(s):
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-Aldh1L1抗体，克隆N103/39, clone N103/39, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
N103/39, monoclonal
species reactivity
human, rat, mouse
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ALDH1L1(10840)
Analysis Note
对照
小鼠脑组织裂解物
小鼠脑组织裂解物
通过蛋白质印迹在小鼠脑组织裂解液中进行了评估。
蛋白质印迹分析：0.5 µg/mL的该抗体可在10 µg小鼠脑组织裂解物中检测到Aldh1L1。
蛋白质印迹分析：0.5 µg/mL的该抗体可在10 µg小鼠脑组织裂解物中检测到Aldh1L1。
Application
抗Aldh1L1克隆N103/39是靶向Aldh1L1蛋白的抗体，已验证可用于免疫荧光、免疫组织化学和蛋白质印迹。
研究子类别
感官 & PNS
感官 & PNS
研究类别
神经科学
神经科学
蛋白质印迹分析：0.5 µg/mL的代表性批次在10 µg人脑组织裂解物中检测到Aldh1L1。
免疫组织化学分析：一个代表性批次以1:2,000的稀释度在大鼠大脑皮层组织和人脑桥/中脑组织中检测到Aldh1L1。
免疫荧光分析：一个代表性批次在大鼠皮质和小脑组织中检测到Aldh1L1。
免疫组织化学分析：一个代表性批次以1:2,000的稀释度在大鼠大脑皮层组织和人脑桥/中脑组织中检测到Aldh1L1。
免疫荧光分析：一个代表性批次在大鼠皮质和小脑组织中检测到Aldh1L1。
Biochem/physiol Actions
该Aldh1L1单克隆抗体不表现出与Aldh1L2的交叉反应性。
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
General description
Aldh1L1，也称为10-甲酰基四氢叶酸脱氢酶（10-FTHFDH），是一种多结构域蛋白，存在于肝细胞溶胶中，也可作为CNS星形胶质细胞标志物。Aldh1L1由两个功能不相关的结构域组成，一个醛脱氢酶同源结构域和一个叶酸结合水解酶结构域。认为这两个结构域通过100个残基的接头连接。已知在Ser6诱导p53磷酸化，这是刺激细胞凋亡的关键步骤。
观测分子量〜99 kDa
Immunogen
重组全长大鼠Aldh1L1。
Other Notes
浓度：关于批次特定浓度请参见检验报告。
Physical form
形式：纯化
纯化的小鼠IgG1κ，溶于含0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05%叠氮化钠的缓冲液中。
纯化蛋白G
Preparation Note
自接收之日起，在2-8°C下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
New ?- and ?-synuclein immunopathological lesions in human brain.
Surgucheva, I; Newell, KL; Burns, J; Surguchov, A
Acta Neuropathologica Communications null
Sheila Espírito-Santo et al.
Glia, 69(6), 1429-1443 (2021-01-27)
Central nervous system (CNS) function depends on precise synaptogenesis, which is shaped by environmental cues and cellular interactions. Astrocytes are outstanding regulators of synapse development and plasticity through contact-dependent signals and through the release of pro- and antisynaptogenic factors. Conversely
Jeremy S Rabinowitz et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(5), E717-E726 (2017-01-18)
Regeneration requires cells to regulate proliferation and patterning according to their spatial position. Positional memory is a property that enables regenerating cells to recall spatial information from the uninjured tissue. Positional memory is hypothesized to rely on gradients of molecules
Gajanan Sathe et al.
Journal of neurochemistry, 156(6), 988-1002 (2020-07-03)
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by intracellular formation of neurofibrillary tangles and extracellular deposition of β-amyloid protein (Aβ) in the extracellular matrix. The pathogenesis of AD has not yet been fully elucidated and little is known
Maria de Los Angeles Castillo-Rodriguez et al.
Histochemistry and cell biology, 158(1), 15-38 (2022-04-06)
Myelin loss with consecutive axon degeneration and impaired remyelination are the underlying causes of progressive disease in patients with multiple sclerosis. Astrocytes are suggested to play a major role in these processes. The unmasking of distinct astrocyte identities in health
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