MABN449
Anti-Protein capicua homolog (CIC), clone 6E12.1 Antibody
clone 6E12.1, 1 mg/mL, from mouse
别名:
Protein capicua homolog, Protein capicua homolog (CIC)
产品名称
Anti-Protein capicua homolog (CIC), clone 6E12.1 Antibody, clone 6E12.1, 1 mg/mL, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
6E12.1, monoclonal
species reactivity
human, rat
concentration
1 mg/mL
technique(s)
immunohistochemistry: suitable (paraffin)
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CIC(23152)
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Analysis Note
Evaluated by Immunohistochemistry in rat cerebellum tissue.
Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected Protein capicua homolog (CIC) in rat cerebellum tissue.
Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected Protein capicua homolog (CIC) in rat cerebellum tissue.
Application
Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected Protein capicua homolog (CIC) in human cerebral cortex, rat olfactory bulb, and rat cerebral cortex tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
This Anti-Protein capicua homolog (CIC), clone 6E12.1 Antibody is validated for use in Immunohistochemistry (Paraffin) for the detection of Protein capicua homolog (CIC).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
164 kDa calculated
Protein capicua homolog (CIC) , also known as Capicua Transcriptional Repressor, Capicua Homolog, and encoded by the gene CIC, is a transcriptional repressor which plays a role in development of the central nervous system (CNS). CIC is a new subfamily of the HMG-box superfamily and the gene′s expression is predominantly restricted to immature granule cells in the cerebellum, hippocampus and olfactory bulb in the CNS, and thus the gene is implicated in CNS development, in particular in granule cell development. CIC appears to be central to cerebellar development and ErbB signaling as well. Recent research has demonstrated that CIC is highly expressed in certain cancers including medulloblastomas, but also the loss of expression may serve as a biomarker for other cancer types such as oligodendrogliomas.
Immunogen
GST-tagged recombinant protein corresponding to human Protein capicua homolog (CIC).
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Severa Bunda et al.
Nature communications, 10(1), 661-661 (2019-02-10)
Capicua (CIC) is a transcriptional repressor that counteracts activation of genes downstream of receptor tyrosine kinase (RTK)/Ras/ERK signaling. It is well-established that tumorigenesis, especially in glioblastoma (GBM), is attributed to hyperactive RTK/Ras/ERK signaling. While CIC is mutated in other tumors
Severa Bunda et al.
Molecular cancer research : MCR, 18(5), 774-786 (2020-02-08)
Capicua (CIC) is a transcriptional repressor that counteracts activation of genes in response to receptor tyrosine kinase (RTK)/Ras/ERK signaling. Following activation of RTK, ERK enters the nucleus and serine-phosphorylates CIC, releasing it from its targets to permit gene expression. We
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持