MABN310
抗-G蛋白偶联受体56（GPR56）抗体，克隆H11
clone H11, from mouse
别名:
G protein-coupled receptor 56, 7-transmembrane protein with no EGF-like N-terminal domains-1, Protein TM7XN1, G-protein coupled receptor 56
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
H11, monoclonal
Application:
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
mouse
Citations:
6
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-G蛋白偶联受体56（GPR56）抗体，克隆H11, clone H11, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
H11, monoclonal
species reactivity
mouse
species reactivity (predicted by homology)
human (based on 100% sequence homology)
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GPR56(9289)
Physical form
形式：纯化
纯化的小鼠单克隆IgG1κ，溶于含0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05%叠氮化钠的缓冲液中。
纯化蛋白G
Immunogen
小鼠GPR56的N末端片段
Other Notes
浓度：关于批次特定浓度请参见检验报告。
Analysis Note
对照
来自E13-E14小鼠的脑组织裂解物
来自E13-E14小鼠的脑组织裂解物
通过蛋白质印迹法在E13-E14小鼠的脑组织裂解物中进行评估。
蛋白质印迹分析：0.5 μg/mL的该抗体在10µg E13-E14小鼠的脑组织裂解物中检测到G-蛋白偶联受体56。
蛋白质印迹分析：0.5 μg/mL的该抗体在10µg E13-E14小鼠的脑组织裂解物中检测到G-蛋白偶联受体56。
Application
免疫组织化学分析：一个代表性批次已被独立实验室用于小鼠脑组织。（Luo，R.，et al.（2011）.Proc Natl Acad Sci U S A. 108（31）:12925-12930.）
免疫细胞化学分析： 一个代表性批次已被独立实验室用于脑膜成纤维细胞(MF)。（Luo，R.，et al.（2011）.Proc Natl Acad Sci U S A. 108（31）:12925-12930.）
免疫细胞化学分析： 一个代表性批次已被独立实验室用于脑膜成纤维细胞(MF)。（Luo，R.，et al.（2011）.Proc Natl Acad Sci U S A. 108（31）:12925-12930.）
研究子类别
粘附(CAMs)
粘附(CAMs)
研究类别
神经科学
神经科学
该抗G蛋白偶联受体56（GPR56）抗体（克隆H11）经验证可用于蛋白质印迹、ICC、IHC检测G蛋白偶联受体56（GPR56）。
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
General description
G蛋白偶联受体56（GPR56）是一种普遍存在的粘附受体，属于G蛋白偶联受体2家族和LN-TM7亚家族。它在甲状腺、脑、心脏和各种肿瘤细胞中大量表达。先前的研究表明，GPR56可能通过与细胞外基质蛋白（例如组织转谷氨酰胺酶）相互作用来抑制黑色素瘤的进展和转移。GPR56还通过PKCα介导的途径在调节VEGF的产生和血管生成中发挥作用。GPR56在额叶皮层的发育中也起着至关重要的作用。先前的研究报道，GPR56中的突变会导致皮层分层紊乱，这在额叶皮层中最为明显。这种情况被称为双侧额顶多小脑回畸形或BFPP。
观测分子量〜62 kDa。全长GPR56（GPR56FL）以75 kDa迁移，而GPR56的裂解胞外域（GPR56ECD）以62 kDa迁移（J Biol Chem. 2008 May 23；283（21）:14469-78）。
Preparation Note
自接收之日起，在2-8°C下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
D Daria et al.
Leukemia, 30(8), 1734-1741 (2016-04-12)
The G protein-coupled receptor 56 (GPR56) was identified as part of the molecular signature of functionally validated leukemic stem cells isolated from patients with acute myeloid leukemia (AML). This report now demonstrates particularly high expression of GPR56 in patients with
Oladapo E Olaniru et al.
Molecular metabolism, 53, 101285-101285 (2021-07-06)
Members of the adhesion G protein-coupled receptor (aGPCR) subfamily are important actors in metabolic processes, with GPR56 (ADGRG1) emerging as a possible target for type 2 diabetes therapy. GPR56 can be activated by collagen III, its endogenous ligand, and by
Gabriel S Salzman et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(38), 10095-10100 (2017-09-07)
Adhesion G protein-coupled receptors (aGPCRs) play critical roles in diverse biological processes, including neurodevelopment and cancer progression. aGPCRs are characterized by large and diverse extracellular regions (ECRs) that are autoproteolytically cleaved from their membrane-embedded signaling domains. Although ECRs regulate receptor
Shih-Chia Huang et al.
EMBO molecular medicine, 9(12), 1660-1680 (2017-10-11)
Lymph node (LN) metastasis is commonly associated with systemic distant organ metastasis in human breast cancer and is an important prognostic predictor for survival of breast cancer patients. However, whether tumor-draining LNs (TDLNs) play a significant role in modulating the
Ayako Y Murayama et al.
Scientific reports, 10(1), 21516-21516 (2020-12-11)
GPR56, a member of the adhesion G protein-coupled receptor family, is abundantly expressed in cells of the developing cerebral cortex, including neural progenitor cells and developing neurons. The human GPR56 gene has multiple presumptive promoters that drive the expression of
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