Anti-CLN6 Antibody, clone N400/24

Ceroid-lipofuscinosis neuronal protein 6 (UniProt: Q9NWW5; also known as CLN6) is encoded by the CLN6 gene (Gene ID: 54982) in human. CLN6 is a multi-pass membrane protein that is localized to endoplasmic reticulum and contributes to lysosomal function and viability of neurons. It has no homology with known proteins or functional domains, however it is highly conserved across mammalian species. Mutations in CLN6 gene have been linked to ceroid lipofuscinosis, neuronal 6 and 4A that are characterized by intracellular accumulation of autofluorescent liposomal material, seizures, dementia, visual loss, and/or cerebral atrophy. Two isoforms of CLN6 have been described that are produced by alternative splicing.

Clone N400/24 specifically detects human Ceroid-lipofuscinosis neuronal protein 6. It does not cross-react with other CLN proteins.

Recombinant fragments corresponding to 54, 47, and 30 amino acids from non-helical regions from the N-terminal, internal, and C-terminal regions of human Ceroid-lipofuscinosis neuronal protein 6 (CLN6).

Anti-CLN6, clone N400/24, Cat. No. MABN2548, is a highly specific mouse monoclonal antibody that targets CLN6 and has been tested for use in Immunohistochemistry (Paraffin).

Research Category
Neuroscience

Evaluated by Immunohistochemistry (Paraffin) in human stomach tissue sections.

Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected CLN6 in human stomach tissue sections.

35.92 kDa calculated.

Protein G purified

Format: Purified

Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Concentration: Please refer to lot specific datasheet.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.