生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
10D9.1, monoclonal
种属反应性
rat, human
技术
immunohistochemistry: suitable
western blot: suitable
同位素/亚型
IgG2aκ
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... DENR(8562)
一般描述
The protein named density-regulated protein (DRP1), also known as DRP, or Protein DRP1 or Smooth muscle cell-associated protein 3 (SMAP-3), and encoded by the gene DENR/DRP1, is an important translational control protein that appears to function by scanning target mRNAs for the recognition codon when complexed with the translational initiation complex. DRP1 also modulates the translation of particular cancer-related mRNAs when recruited to the translational complex by the oncogene MCTS1 and DRP1 is up regulated in many cancers such as ovarian and breast cancers. Additionally, DRP1’s expression is regulated by increasing cell density through interaction with heterogeneous nuclear ribonucleoprotein D (HNRNPD) protein, a critical protein that complexes with heterogeneous nuclear RNA and pre-mRNAs and fosters mRNA stability. Density-regulated protein (DRP1) is localized to the in heart, skeletal muscle, brain, placenta, liver and pancreas, with weaker expression seen in lung and kidney.
免疫原
GST-tagged recombinant protein corresponding to the C-terminus of human DENR.
应用
Anti-DENR Antibody, clone 10D9.1 is a mouse monoclonal antibody, validated for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected DENR in human cerebral cortex and human cardiac myocytes tissue.
质量
Evaluated by Western Blotting in PC-12 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected DENR in 10 µg of PC-12 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected DENR in 10 µg of PC-12 cell lysate.
目标描述
~22 kDa observed. Uncharacterized band(s) may appear in some lysates.
外形
Format: Purified
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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