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生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
7G1.1, monoclonal
种属反应性
rat, mouse, human
技术
immunohistochemistry: suitable (paraffin)
western blot: suitable
同位素/亚型
IgG1κ
NCBI登记号
UniProt登记号
运输
ambient
靶向翻译后修饰
unmodified
基因信息
human ... DPP6(1804)
一般描述
Dipeptidyl aminopeptidase-like protein 6 (UniProt: P42658; also known as DPPX, Dipeptidyl aminopeptidase-related protein, Dipeptidyl peptidase 6, Dipeptidyl peptidase IV-like protein, Dipeptidyl peptidase VI, DPP VI) is encoded by the DPP6 gene (Gene ID: 1804) in human. DPP6 is a type II membrane glycoprotein of the dipeptydilaminopeptidase-like proteins (DPPLs) subfamily. DPP6 has a short cytoplasmic domain, a long extracellular domain and a transmembrane domain. DPP6 is an inactive protease homolog that is an important regulator of CG cell excitability. It is widely expressed in the brain where it co-assembles with KCND2 channels and KChIP auxiliary subunits to regulate the amplitude and functional properties of the somatodendritic A-current, ISA. DPP6 is reported to promote cell surface expression of KCND2 and modulates it s the activity and gating characteristics. Defects in DPP6 gene have been linked to familial paroxysmal ventricular fibrillation 2, which is characterized by cardiac arrhythmia marked by fibrillary ventricular muscle contractions. In addition, DPP6 mutations are reported to cause mental retardation, autosomal dominant 33 (MRD33) characterized by mental retardation associated with microcephaly and impairments in adaptive behavior.
特异性
Clone 7G1.1 detected DPP6 in mouse brain.
免疫原
GST-tagged recombinant fragement corresponding to 72 amino acids from the N-terminal half of human DPP6.
应用
Anti-DPP6 antibody, clone 7G1.1, Cat. No. MABN2186, is a highly specific mouse monoclonal antibody that targets DPP6 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
Research Category
Neuroscience
Neuroscience
Western Blotting Analysis: 0.5 µg/mL from a representative lot detected DPP6 in 10 µg of human fetal brain tissue lysate.
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected DPP6 in human cerebral cortex, human cerebellum, rat cerebral cortex, and rat cerebellum tissue.
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected DPP6 in human cerebral cortex, human cerebellum, rat cerebral cortex, and rat cerebellum tissue.
质量
Evaluated by Western Blotting in mouse brain tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected DPP6 in 10 µg of mouse brain tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected DPP6 in 10 µg of mouse brain tissue lysate.
目标描述
~100 kDa observed; 97.59 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
外形
Protein G purified
Format: Purified
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
其他说明
Concentration: Please refer to lot specific datasheet.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
法规信息
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