MABN153
Anti-HuC/HuD Antibody, clone 15A7.1
clone 15A7.1, from mouse
别名:
ELAV-like protein 3, Hu-antigen C, HuC, Paraneoplastic cerebellar degeneration-associated antigen, Paraneoplastic limbic encephalitis antigen 21, ELAV-like protein 4, Hu-antigen D, HuD, Paraneoplastic encephalomyelitis antigen HuD
产品名称
Anti-HuC/HuD Antibody, clone 15A7.1, clone 15A7.1, from mouse
isotype
IgG2aκ
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
15A7.1, monoclonal
species reactivity
human, rat, mouse
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ELAVL4(1996)
Analysis Note
Control
Human brain tissue lysate
Human brain tissue lysate
Evaluated by Western Blotting in human brain tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected HuC/HuD in 200 µg of human brain tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected HuC/HuD in 200 µg of human brain tissue lysate.
Application
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected HuC/HuD in human brain and rat hippocampus tissues.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
This HuC/HuD antibody is validated for use in WB & IHC for the detection of the HuC/HuD protein.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Hu proteins are mammalian embryonic lethal abnormal visual system (ELAV)-like neuronal RNA-binding proteins that contain three RNA recognition motifs. RNA binding protein HuC promotes neuronal development in both the central and the peripheral nervous systems. HuC antibodies are used as markers for developing neurons. HuD may play a role in neuron-specific RNA processing, and be involved in maintaining the proliferative state of cells.
~ 40 kDa observed. An uncharacterized band may appear at ~45 kDa in some lysates.
Immunogen
KLH-conjugated linear peptide corresponding to human HuC/HuD.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Karolína Liška et al.
Neuroendocrinology, 112(4), 384-398 (2021-06-11)
Circadian clocks in the hippocampus (HPC) align memory processing with appropriate time of day. Our study was aimed at ascertaining the specificity of glycogen synthase kinase 3-beta (GSK3β)- and glucocorticoid (GC)-dependent pathways in the entrainment of clocks in individual HPC
Christine Marques et al.
Acta neuropathologica, 147(1), 56-56 (2024-03-13)
The stimulator of interferon genes (STING) pathway has been implicated in neurodegenerative diseases, including Parkinson's disease and amyotrophic lateral sclerosis (ALS). While prior studies have focused on STING within immune cells, little is known about STING within neurons. Here, we
Joslyn Lay et al.
American journal of physiology. Gastrointestinal and liver physiology, 311(2), G252-G266 (2016-07-02)
The μ-opioid receptor (MOR) is a major regulator of gastrointestinal motility and secretion and mediates opiate-induced bowel dysfunction. Although MOR is of physiological and therapeutic importance to gut function, the cellular and subcellular distribution and regulation of MOR within the
Yaxing Gui et al.
Brain pathology (Zurich, Switzerland), 30(1), 151-164 (2019-07-06)
The 18 kDa translocator protein (TSPO) is a widely used target for microglial PET imaging radioligands, but its expression in post-mortem normal and diseased human brain is not well described. We aimed at characterizing the TSPO expression in human control
Clara Muñoz-Castro et al.
Methods in molecular biology (Clifton, N.J.), 2593, 283-305 (2022-12-14)
There is a growing interest in expanding the multiplexing capability of immunohistochemistry to achieve a deeper phenotyping of various cell types in health and disease. Here, we describe a protocol of cyclic multiplex fluorescent immunohistochemistry that enables the labeling of
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