MABF81
抗-ROR γT抗体，克隆6F3.1
clone 6F3.1, from mouse
别名:
Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Retinoid-related orphan receptor-gamma
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
6F3.1, monoclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
human
Citations:
21
Technique(s):
immunohistochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-ROR γT抗体，克隆6F3.1, clone 6F3.1, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
6F3.1, monoclonal
species reactivity
human
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... RORC (6097)
Analysis Note
对照
T47D细胞裂解物
T47D细胞裂解物
通过蛋白质印迹法在T47D细胞裂解物中进行评估。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg的T47D细胞裂解物中检测到RORγT。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg的T47D细胞裂解物中检测到RORγT。
Application
免疫组织化学分析：该抗体以1:50稀释度在正常人肝组织中检测到RORγT。
研究子类别
炎症 & 自身免疫机制
炎症 & 自身免疫机制
研究类别
炎症 & 免疫学
炎症 & 免疫学
经验证，该抗RORγT抗体（克隆6F3.1）可用于WB、IH中检测RORγT。
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
General description
类视黄醇相关的孤儿受体-γ t(RORγT)是属于核激素受体家族的两种RORγ亚型之一，并包含单个核受体DNA结合结构域。RORγT是TNFDF6/FasL表达和IL2的T细胞产生的负调节剂。RORγT的上调是TH17细胞分化的要求。TGF-β’s与Foxp3的相互作用诱导了RORγT的抑制。主要在未成熟的胸腺细胞中观察到表达，并且在胎儿发育过程中，仅在淋巴诱导（LTi）细胞中发现表达。
观测分子量〜55 kDa。在一些细胞裂解物中可观察到~55 kDa和~58 kDa的两种亚型。
Immunogen
GST标记的重组蛋白，对应于人RORγt。
Other Notes
浓度：关于批次特定浓度请参见检验报告。
Physical form
形式：纯化
纯化的小鼠单克隆IgG2aκ，溶于含0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
纯化蛋白G
Preparation Note
自接收之日起，在2-8°C下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
D Croxatto et al.
Mucosal immunology, 9(6), 1372-1383 (2016-02-26)
Innate lymphoid cells (ILCs) have a central role in innate defenses against pathogens, lymphoid organogenesis, and tissue remodeling. They have been detected in human decidua, however, their role in this tissue remains unclear. Successful pregnancy requires an early inflammatory phase
Yared Hailemichael et al.
Cancer cell, 40(5), 509-523 (2022-05-11)
Immune checkpoint blockade (ICB) therapy frequently induces immune-related adverse events. To elucidate the underlying immunobiology, we performed a deep immune analysis of intestinal, colitis, and tumor tissue from ICB-treated patients with parallel studies in preclinical models. Expression of interleukin-6 (IL-6)
Joan Gil et al.
Biomedicines, 10(2) (2022-02-26)
Acromegaly is caused by excess growth hormone (GH) produced by a pituitary tumor. First-generation somatostatin receptor ligands (SRLs) are the first-line treatment. Several studies have linked E-cadherin loss and epithelial-mesenchymal transition (EMT) with resistance to SRLs. Our aim was to
Aoi Okubo et al.
International journal of molecular sciences, 23(1) (2022-01-12)
Th17 cells play an important role in psoriasis. The differentiation of naïve CD4+ T cells into Th17 cells depends on glycolysis as the energy source. CD147/basigin, an integral transmembrane protein belonging to the immunoglobulin superfamily, regulates glycolysis in association with
Huai-Chia Chuang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(10), 11469-11480 (2019-07-19)
The cytokine IL-17A plays critical roles in the pathogenesis of autoimmune diseases. The frequencies of MAP kinase kinase kinase kinase 3 [also named germinal center kinase-like kinase (GLK)]-overexpressing T cells are correlated with disease severity of systemic lupus erythematosus (SLE).
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