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Merck
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主要文件

MABF157E

Sigma-Aldrich

Anti-CD3e (Mouse), clone 145-2C11, biotin conjugate Antibody

clone 145-2C11, from hamster(Armenian), purified by affinity chromatography

别名:

T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3e

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.45

生物来源

hamster (Armenian)

质量水平

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

145-2C11, monoclonal

纯化方式

affinity chromatography

种属反应性

mouse

包装

antibody small pack of 25 μg

技术

flow cytometry: suitable

同位素/亚型

IgG

UniProt登记号

靶向翻译后修饰

unmodified

基因信息

mouse ... Cd3E(12501)

一般描述

The 145-2C11 antibody is specific for mouse CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.The 145-2C11 antibody is a widely used phenotypic marker for mouse T cells. In addition, binding of 145-2C11 antibody to CD3e can induce cell activation. A recent publication of the crystal structure of a murine CD3e-mitogenic antibody complex provides further insight into the action of commonly used agonist antibodies (Fernandes, R.A. et al. 2012. J. Biol. Chem. 287: 13324-13335).

应用

Anti-CD3e (Mouse), clone 145-2C11, biotin conjugate Antibody detects level of CD3e and has been published and validated for use in Flow Cytometry.

质量

This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.125 μg from a representative lot detected CD3e in one million C57Bl/6 splenocytes.

其他说明

Concentration: Please refer to lot specific datasheet.

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储存分类代码

12 - Non Combustible Liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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