MABF1514
Anti-IL-12/IL-23 p40 (mouse), PE, clone C17.8 Antibody
clone C17.8, from rat, PE
别名:
Interleukin-12 subunit beta (IL-12B), Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40), IL-12 subunit p40, IL-12/IL-23 p40
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所有图片(1)
About This Item
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
生物来源
rat
质量水平
偶联物
PE
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
C17.8, monoclonal
种属反应性
mouse
技术
flow cytometry: suitable
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
mouse ... Il12B(16160)
相关类别
一般描述
The C17.8 antibody is specific for the 40 kDa (p40) protein subunit shared by the cytokines IL-12 and IL-23. To form IL-12, p40 assembles with a separate 35 kDa protein known as p35, resulting in a 70 kDa functional cytokine. IL-12 is secreted by activated monocytes, macrophages, and dendritic cells, and has been shown to target naïve, resting CD4+ T cells to promote their proliferation and secretion of cytokines. IL-23 contains the p40 subunit in combination with a 19 kDa protein chain, p19; its primary source being activated dendritic cells and other antigen-presenting cells. IL-23 appears to target different cell types than IL-12, acting on memory CD4+ T cells to induce a strong proliferative response and contributing to the generation and expansion of Th17 cells. Like the cytokines themselves, the receptors for IL-12 and IL-23 share one subunit, as well as containing distinct cytokine-specific subunits.As the C17.8 antibody binds to a shared subunit of both IL-12 and IL-23, it may be used as a marker for either IL-12 or IL-23 expression in dendritic cells, monocytes and macrophages, and is widely used for neutralization of activity associated with either cytokine. Please choose the appropriate format for each application.
Anti-IL-12/IL-23 p40 (mouse), PE, clone C17.8 Antibody is an antibody against IL-12 for use in Flow Cytometry.
质量
This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.
Flow Cytometry Analysis: 0.125 μg from a representative lot detected IL-12/IL-23 p40 in mouse macrophages.
Flow Cytometry Analysis: 0.125 μg from a representative lot detected IL-12/IL-23 p40 in mouse macrophages.
其他说明
Concentration: Please refer to lot specific datasheet.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ayako Hino et al.
The American journal of pathology, 164(4), 1327-1335 (2004-03-25)
IL-12 consists of two disulfide-linked subunits, p40 and p35, that form functionally active heterodimers for the induction of Th1 cells. In contrast to IL-12 heterodimers, p40 monomers and homodimers possess inhibitory effects on Th1 cells leading to the creation of
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