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生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
hT2H21F11, monoclonal
种属反应性
human, mouse
技术
ChIP: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型
IgG1κ
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... TET2(54790)
一般描述
甲基胞嘧啶双加氧酶TET2催化甲基胞嘧啶（5mC）向5-羟甲基胞嘧啶（5hmC）的转化。目前尚不清楚5-羟甲基胞嘧啶的功能，但它可能影响染色质结构，或充当胞嘧啶去甲基化的中间成分。TET2经常在骨髓增生性疾病(MPD)或骨髓增生性肿瘤(MPN)和全身性肥大细胞增多症中发生突变。TET2疾病还会引起真性红细胞增多症(PV)和骨髓增生异常综合症(MDS)。
特异性
该抗体识别TET2的N末端
免疫原
对应于人TET2 N末端的重组蛋白。
应用
使用该小鼠单克隆抗体（抗TET2抗体，克隆hT2H 21F11）检测Tet2，该抗体经验证可用于染色质IP（ChIP）和蛋白质印迹& IP。
蛋白质印迹分析：1.0 µg/mL的代表性批次在10 µg TF-1细胞裂解物中检测到TET2。
免疫沉淀分析：5 µg的代表性批次在250 µg HL60 RIPA细胞裂解物中免疫沉淀TET2。
免疫沉淀分析：5 µg的代表性批次在250 µg HL60 RIPA细胞裂解物中免疫沉淀TET2。
质量
通过蛋白质印迹法在MOLT-4细胞裂解物中进行评价。
蛋白质印迹分析：1.0 µg/mL的该抗体在10µg MOLT-4细胞裂解物中检测到TET2。
蛋白质印迹分析：1.0 µg/mL的该抗体在10µg MOLT-4细胞裂解物中检测到TET2。
目标描述
观测分子量〜260 kDa。该蛋白的计算分子量为224 kDa，但可在约260 kDa处观察到
外形
形式：纯化
分析说明
对照
MOLT-4细胞裂解物
MOLT-4细胞裂解物
其他说明
浓度：关于批次特定浓度请参见检验报告。
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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