生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
hT2H21F11, monoclonal
种属反应性
human, mouse
技术
ChIP: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型
IgG1κ
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... TET2(54790)
一般描述
甲基胞嘧啶双加氧酶TET2催化甲基胞嘧啶（5mC）向5-羟甲基胞嘧啶（5hmC）的转化。目前尚不清楚5-羟甲基胞嘧啶的功能，但它可能影响染色质结构，或充当胞嘧啶去甲基化的中间成分。TET2经常在骨髓增生性疾病(MPD)或骨髓增生性肿瘤(MPN)和全身性肥大细胞增多症中发生突变。TET2疾病还会引起真性红细胞增多症(PV)和骨髓增生异常综合症(MDS)。
特异性
该抗体识别TET2的N末端
免疫原
对应于人TET2 N末端的重组蛋白。
应用
使用该小鼠单克隆抗体（抗TET2抗体，克隆hT2H 21F11）检测Tet2，该抗体经验证可用于染色质IP（ChIP）和蛋白质印迹& IP。
蛋白质印迹分析：1.0 µg/mL的代表性批次在10 µg TF-1细胞裂解物中检测到TET2。
免疫沉淀分析：5 µg的代表性批次在250 µg HL60 RIPA细胞裂解物中免疫沉淀TET2。
免疫沉淀分析：5 µg的代表性批次在250 µg HL60 RIPA细胞裂解物中免疫沉淀TET2。
质量
通过蛋白质印迹法在MOLT-4细胞裂解物中进行评价。
蛋白质印迹分析：1.0 µg/mL的该抗体在10µg MOLT-4细胞裂解物中检测到TET2。
蛋白质印迹分析：1.0 µg/mL的该抗体在10µg MOLT-4细胞裂解物中检测到TET2。
目标描述
观测分子量〜260 kDa。该蛋白的计算分子量为224 kDa，但可在约260 kDa处观察到
外形
形式：纯化
分析说明
对照
MOLT-4细胞裂解物
MOLT-4细胞裂解物
其他说明
浓度：关于批次特定浓度请参见检验报告。
Not finding the right product?
Try our 产品选型工具.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Yueyue Duan et al.
Journal of medical virology, 94(7), 3251-3256 (2022-02-26)
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a newly discovered bat-origin coronavirus with fatal pathogenicity for neonatal piglets. There is no vaccine to prevent SADS-CoV infection or clinically approved drugs targeting SADS-CoV. Therefore, unraveling cellular factors that regulate SADS-CoV for
Lijuan Luo et al.
iScience, 27(3), 109252-109252 (2024-03-05)
DNA demethylase TET2 was related with lung function. However, the precise role of TET2 in cigarette smoke (CS)-induced apoptosis of airway epithelium cells, and the mechanisms involved, have yet to be elucidated. Here, we showed that CS decreased TET2 protein
Zihang Zeng et al.
Redox biology, 67, 102916-102916 (2023-10-10)
Chronic obstructive pulmonary disease (COPD) is a significant global cause of morbidity and mortality currently. Long-term exposure of cigarette smoke (CS) inducing persistent inflammation, small airway remodeling and emphysematous lung are the distinguishing features of COPD. Ferroptosis, occurred in lung
Lei-Lei Chen et al.
Science advances, 6(38) (2020-09-20)
TET2 DNA dioxygenase is frequently mutated in human hematopoietic malignancies and functionally inactivated in many solid tumors through a nonmutational mechanism. We recently found that TET2 mediates the interferon-JAK-STAT pathway to stimulate chemokine expression and tumor infiltration of lymphocytes (TILs).
Marta Prieto-Vila et al.
Journal of extracellular biology, 1(8), e47-e47 (2022-08-03)
Recurrence is one of the major issues in bladder cancer (BCa). Novel technologies, such as the detection of microRNAs carried by extracellular vesicles (EVs) in urine, have been proposed as biomarkers for detecting recurrence in BCa. Although the usefulness of
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门