Anti-Suv4–20h2 Antibody, clone 6B9

Suppressor of variegation 4-20 homolog 2 (Suv4-20h2), also known as Lysine N-methyltransferase 5C (KMT5C), is a Histone-lysine N-methyltransferase that specifically trimethylates Lys-20 of histone H4. Suv4-20h2 mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. In mammals, Histone H4 Lys-20 trimethylation (H4K20me3) is one of the most common chromatin modifications and it has been implicated in various biological processes, including heterochromatin formation, telomere function, imprinting, X inactivation, DNA damage repair and cancer progression.

GST-tagged recombinant protein corresponding to human Suv4-20h2.

Detect the Suv4–20h2 protein using this Anti-Suv4–20h2, clone 6B9 validated for use in WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Chromatin Biology

Evaluated by Western Blot in H9 human embryonic stem cell lysate.

Western Blot Analysis: 4.0 µg/mL of this antibody detected Suv4-20h2 in 10 µg of H9 human embryonic stem cell lysate.

~53 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~11 kDa and ~15 kDa

Protein G Purified

Format: Purified

Purified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
H9 human embryonic stem cell lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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