Anti-IGF2BP2 Antibody, clone 5E10-3E1

Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is a member of the IGF-II mRNA binding protein family that posttranscriptionally regulates IGF2 during developmental stages. IGF2 mRNA-binding protein family members (IGF2BP1, 2 and 3) bind UTR region of IGF2 transcripts and are implicated in the transport of RNA targets to enable protein synthesis at specific locations in the cytoplasm. Studies have indicated variations in the IGF2BP2 gene may affect fetal glucose metabolism and plays a role in type 2 diabetes. In addition to playing a role in glucose metabolism and dieabetes, the insulin-like growth factor (IGF) signaling axis plays an important role in cancer biology. Research has shown IGF2 to be emerging as an important gene for ovarian cancer.

Histidine-tagged recombinant protein corresponding to human IGF2BP2.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
RNA Metabolism & Binding Proteins

Use Anti-IGF2BP2 Antibody, clone 5E10-3E1 (mouse monoclonal antibody) validated in WB to detect IGF2BP2 also known as Insulin-like growth factor 2 mRNA-binding protein 2, IGF2 mRNA-binding protein 2, IMP-2, Hepatocellular carcinoma autoantigen p62.

Evaluated by Western Blot in HepG2 cell lysate.

Western Blot Analysis: A 1:20,000 dilution of this antibody detected IGF2BP2 on 10 µg of HepG2 cell lysate.

~66 kDa observed. An uncharacterized band at ~50 kDa may be observed in some lysates. Alternative splicing can result in 5 isoforms with molecular weights ranging from 55-66 kDa

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
HepG2 cell lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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