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Merck
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MABD24A4

Sigma-Aldrich

Anti-NANOG Antibody, clone 7F7.1, Alexa Fluor™ 488 conjugate

clone 7F7.1, from mouse, ALEXA FLUOR™ 488

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别名:
Homeobox protein NANOG, Homeobox transcription factor Nanog, hNanog
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

mouse

质量水平

100

偶联物

ALEXA FLUOR™ 488

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

7F7.1, monoclonal

种属反应性

human

技术

immunocytochemistry: suitable

同位素/亚型

IgG2a

NCBI登记号

NP_079141

UniProt登记号

Q9H9S0

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... NANOG(79923)

一般描述

NANOG (Homeobox protein NANOG) is a member of the Nanog homeobox family of DNA-binding proteins. It is expressed in embryonic stem cells and confers pluripotency on these cells. Once embryonic stem cells become differentiated, NANOG expression is suppressed. NANOG is involved in the Hedgehog/Gli1 signaling pathway which has been implicated in the development and growth of various types of tumors. NANOG has also been identified as a key transcription factor used to generate induced pluripotent stem cells.

应用

Anti-NANOG Antibody, clone 7F7.1, Alexa Fluor 488 conjugate.

质量

Evaluated by Immunocytochemistry in H9 human embryonic stem cells. Immunocytochemsitry Analysis: A 1:100 dilution of this antibody detected NANOG in H9 human embryonic stem cells.

目标描述

The uncojugated parent antibody (Catalog No. MABD24) has an observed MW of 39 kDa

外形

Purified mouse monoclonal IgG2a conjugated to Alexa Fluor™ 488 in PBS with 0.1% sodium azide and 15mg/ml BSA.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

ALEXA FLUOR is a trademark of Life Technologies

WGK

WGK 2

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Breanna S Borys et al.
Stem cell research & therapy, 12(1), 55-55 (2021-01-14)
Human induced pluripotent stem cells (hiPSCs) hold enormous promise in accelerating breakthroughs in understanding human development, drug screening, disease modeling, and cell and gene therapies. Their potential, however, has been bottlenecked in a mostly laboratory setting due to bioprocess challenges
Breanna S Borys et al.
Stem cells translational medicine, 9(9), 1036-1052 (2020-05-24)
Human induced pluripotent stem cells (hiPSCs) have generated a great deal of attention owing to their capacity for self-renewal and differentiation into the three germ layers of the body. Their discovery has facilitated a new era in biomedicine for understanding
Victor J T Lin et al.
Scientific reports, 7(1), 5005-5005 (2017-07-12)
Despite their well-known function in maintaining normal cell physiology, how inorganic elements are relevant to cellular pluripotency and differentiation in human pluripotent stem cells (hPSCs) has yet to be systematically explored. Using total reflection X-ray fluorescence (TXRF) spectrometry and inductively
Quan Qi et al.
International journal of molecular medicine, 35(3), 569-578 (2014-12-20)
The present study aimed to investigate the X chromosome inactivation (XCI) status in long-term cultured human parthenogenetic embryonic stem cells. One human embryonic stem (hES) cell line and 2 human parthenogenetic embryonic stem (hPES) cell lines were subjected to long-term
Melissa Conti Mazza et al.
Stem cell research, 55, 102506-102506 (2021-08-23)
Mutations in the oncogene PARK7, which codes for DJ-1, have been associated with early-onset autosomal recessive Parkinson's disease (PD); however, the exact role of DJ-1 in PD remains elusive. Fibroblasts from a PD patient with a uniparental disomy, 1 bp deletion
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