Anti-Kallikrein-13/KLK13 Antibody, clone 33.1

Kallikreins-related peptidases (KLKs) are proteases that are important for the desquamation process of the skin (cell shedding). Kallikreins are also associated with carcinogenesis and some serve as a novel cancer and other disease biomarkers. Kallikrein-13/KLK13 is important in lung cancer by allowing lung adenocarcinoma spreading through promoting the expression of various adhesion molecules and it in assisting in extracellular matrix protein degradation necessary for movement. Kallikrein-13/KLK13 also plays a role in salivary tumors and ovarian cancer as well as other cancers in a similar fashion. In both normal and cancerous tissues, Kallikrein-13/KLK13 is secreted into the ECM and expressed in many tissues in both the embryo and adult.

Recombinant protein corresponding to Human Kallikrein-13/KLK13.

Immunohistochemistry Analysis: A representative lot of this antibody detected Kallikrein-13/KLK13 in Normal ovarian surface epithelium and epithelial ovarian cancer tissues (White et al., (2009) British Journal of Cancer. 101:1107-1113).

ELISA: A representative lot of this antibody detected various Kallikrein-13/KLK13 concentrations of several human tissues (Kapadia et al., (2003) Clinical chemistry. 49(1):77–86).

This Anti-Kallikrein-13/KLK13 Antibody, clone 33.1 is validated for use in Immunohistochemistry and ELISA for the detection of Kallikrein-13/KLK13.

Evaluated by Immunohistochemistry in human lung and human prostate tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Kallikrein-13/KLK13 in human prostate tissue.

30 kDa calculated

Format: Purified

Purified mouse monoclonal IgG1k in 0.1 M Sodium Bicarbonate buffer pH8.2 without preservatives.

Concentration: Please refer to lot specific datasheet.