生物来源
mouse
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
8H4.1, monoclonal
种属反应性
human, rat
技术
immunohistochemistry: suitable
western blot: suitable
同位素/亚型
IgG1κ
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... KISS1(3814)
一般描述
转移抑制因子KiSS-1（KiSS-1；或Kisspeptin-1）是孤儿G蛋白偶联受体GPR54的几种内源性配体之一。KiSS-1通过抑制受影响细胞的迁移和增殖，在各种类型的癌症中起着抑制转移的作用。这种作用可能是由多种信号通路的激活产生的: 配体结合的GPR54通过PLC途径激活IP3和PKC信号传导；以及cPLA2引起的ERK 1和ERK 2，这可能分别导致钙信号传导和基因转录增加。然而，最近，KiSS-1/GPR54信号传导与青春期和发育有关。KISS-1/GPR54可能在青春期调节GnRH神经元的信号传导，并可能影响FH和LSH激素的释放。KISS-1在中枢神经系统、睾丸、胰腺、肠、卵巢和胎盘中高度表达。
免疫原
对应于人KiSS-1的重组蛋白。
应用
免疫组织化学分析：一个代表性批次以1:1,000稀释度在人胰腺和大鼠睾丸组织中检测到KiSS-1。
抗KiSS-1抗体，克隆8H4.1是针对KiSS-1的抗体，用于IHC、蛋白质印迹。
质量
通过免疫组织化学在人胎盘组织中进行评价。
免疫组织化学分析：该抗体以1:1,000稀释度在人胎盘组织中检测到KiSS-1。
免疫组织化学分析：该抗体以1:1,000稀释度在人胎盘组织中检测到KiSS-1。
目标描述
计算分子量15 kDa
外形
形式：纯化
其他说明
浓度：关于批次特定浓度请参见检验报告。
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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