MABC32

抗-p62（死骨片-1）抗体，克隆11C9.2

Name: 抗-p62（死骨片-1）抗体，克隆11C9.2
Brand: MM

clone 11C9.2, from mouse

别名:

sequestosome 1, EBI3-associated protein of 60 kDa, Paget disease of bone 3, phosphotyrosine independent ligand for the Lck SH2 domain p62, oxidative stress induced like, EBI3-associated protein p60, Phosphotyrosine-independent ligand for the Lck SH2 doma

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

主要文件

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产品名称

抗-p62（死骨片-1）抗体，克隆11C9.2, clone 11C9.2, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

11C9.2, monoclonal

species reactivity

mouse, rat, human

technique(s)

flow cytometry: suitable
immunocytochemistry: suitable
western blot: suitable

isotype

IgMκ

NCBI accession no.

NP_001135770

UniProt accession no.

Q13501

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SQSTM1(8878)

Analysis Note

对照
A431细胞裂解物

通过蛋白质印迹法在A431细胞裂解物中进行评估。

蛋白质印迹分析：0.001 µg/mL该抗体在10 µg A431细胞裂解物中检测到p62（Sequestosome-1）。

Application

使用经验证可用于WB、FC&IC的抗p62（Sequestosome-1）抗体（克隆11C9.2）检测p62（Sequestosome-1）。

研究子类别
凋亡 - 附加

研究类别
细胞凋亡 & 癌症

蛋白质印迹分析：0.001 µg/mL的先前批次在10 µg PC12细胞裂解物中检测到p62（Sequestosome-1）。

流式细胞术分析：1.0 µg的先前批次在固定和透性化HeLa细胞染色中检测到p62（Sequestosome-1）。

免疫细胞化学分析：一个先前批次以1:500稀释度在NIH/3T3、A431和HeLa细胞中检测到p62（Sequestosome-1）。

Disclaimer

除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。

General description

p62也称为sequestosome-1，是62 kDa ras-GAP相关蛋白。p62被认为与Src家族酪氨酸激酶结合，并且还可以为活化的Src家族激酶及其下游效应子提供接头作用。p62具有RNA结合区，可能具有RNA结合能力。p62与转录因子NF-κB的激活有关，参与细胞分化、免疫反应和钾通道调节。p62最近与外在细胞凋亡有关，可能是肿瘤发生的关键因素。

观测分子量约47-60 kDa。
该蛋白的计算分子量为47 kDa，在38 kDa处也具有亚型。由于修饰，在某些裂解物中可观察到高达〜60 kDa的该蛋白。

Immunogen

GST标记的重组蛋白，对应于人p62（Sequestosome-1）。

Other Notes

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

Physical form

形式：纯化

纯化的小鼠单克隆IgMκ，溶于含0.05%叠氮化钠的PBS的缓冲液中。

Preparation Note

自接收之日起，在2-8°C下可稳定保存1年。

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin.

Yue-Mei Feng et al.

Autophagy, 9(9), 1395-1406 (2013-06-27)

Drug addiction is a chronic brain disease that is a serious social problem and causes enormous financial burden. Because mitochondrial abnormalities have been associated with opiate addiction, we examined the effect of morphine on mtDNA levels in rat and mouse

The regulatory activity of autophagy in conjunctival fibroblasts and its possible role in vernal keratoconjunctivitis.

Paola Brun et al.

The Journal of allergy and clinical immunology, 146(5), 1210-1213 (2020-04-10)

Tissue-specific small heat shock protein 20 activation is not associated with traditional autophagy markers in Ossabaw swine with cardiometabolic heart failure.

Kleiton Augusto Santos Silva et al.

American journal of physiology. Heart and circulatory physiology, 319(5), H1036-H1043 (2020-09-19)

The small heat shock protein 20 (HSPB6) emerges as a potential upstream mediator of autophagy. Although autophagy is linked to several clinical disorders, how HSPB6 and autophagy are regulated in the setting of heart failure (HF) remains unknown. The goal

Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation.

Huimin Yan et al.

Journal of rheumatic diseases and treatment, 1(1), 5-5 (2015-06-30)

Autophagy plays a central role in various disease processes. However, its contribution to inflammatory arthritides such as rheumatoid arthritis (RA) is unclear. We observed that autophagy is engaged in the K/BxN serum transfer model of RA but autophagic flux is

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy.

Michalis Papadakis et al.

Nature medicine, 19(3), 351-357 (2013-02-26)

Previous attempts to identify neuroprotective targets by studying the ischemic cascade and devising ways to suppress it have failed to translate to efficacious therapies for acute ischemic stroke. We hypothesized that studying the molecular determinants of endogenous neuroprotection in two

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抗-p62（死骨片-1）抗体，克隆11C9.2

clone 11C9.2, from mouse

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关于此项目

主要文件

属性

产品名称

biological source

conjugate

antibody form

antibody product type

clone

species reactivity

technique(s)

isotype

NCBI accession no.

UniProt accession no.

shipped in

target post-translational modification

Quality Level

Gene Information

相关类别

说明

Analysis Note

Application

Disclaimer

General description

Immunogen

Other Notes

Physical form

Preparation Note

安全信息

存储类别

wgk

flash_point_f

flash_point_c

文件

分析证书(COA)

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