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Merck
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主要文件

MABC209

Sigma-Aldrich

Anti-MUC13 Antibody, clone 2E11.1

clone 2E11.1, from mouse

别名:

Mucin-13, MUC-13, Down-regulated in colon cancer 1

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

mouse

质量水平

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

2E11.1, monoclonal

种属反应性

human, rat

技术

immunohistochemistry: suitable (paraffin)
western blot: suitable

同位素/亚型

IgG2aκ

NCBI登记号

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... MUC13(56667)

一般描述

Mucin-13 (MUC-13) is also called Down-regulated in colon cancer 1 (DRCC1). MUC-13 is an epithelial and hemopoietic transmembrane mucin that is likely involved in cell signaling. MUC-13 is highly expressed in epithelial tissues (especially in gastrointestinal and respiratory tracts) as well as kidney, small intestine, appendix and stomach.

免疫原

Epitope: This antibody recognizes the cytoplasmic domain within the Beta subunit of MUC-13.
GST-tagged recombinant protein corresponding to the cytoplasmic domain of human MUC-13.

应用

Detect Mucin using this mouse monoclonal antibody, Anti-MUC13 Antibody, clone 2E11.1 validated for use in western blotting & IHC (Paraffin).
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Western Blotting Analysis: 0.5 µg/mL from a representative lot detected MUC-13 in 10 µg of human kidney tissue lysate.

Immunohistochemistry Analysis: a 1:500 dilution from a representative lot detected MUC-13 in human ilium tissues.

质量

Evaluated by Western Blotting in human small intestine tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected MUC-13 in 10 µg of human small intestine tissue lysate.

目标描述

~33 and ~60 kDa observed. Swiss-Prot describes a molecular weight of ~55 kDa Due post-translational modification, this protein is cleaved resulting in beta subunit (~33 kDa) and an alpha subunit (Williams, S. J., et al. (2001). J Biol Chem. 276(21):18327-18336. Maher, D. M., et al. (2011). Mol Cancer Res. 9(5):531-537.). Uncharacterized band(s) may be observed in some cell lysates.

外形

Protein G Purified
Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Tom Breugelmans et al.
Inflammatory bowel diseases, 29(4), 589-601 (2022-10-15)
Intestinal mucosal healing is nowadays preferred as the therapeutic endpoint in inflammatory bowel disease (IBD), but objective measurements at the molecular level are lacking. Because dysregulated mucin expression is suggested to be involved in mucosal barrier dysfunction in IBD, we
IL-22-Activated MUC13 Impacts on Colonic Barrier Function through JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling.
Breugelmans, et al.
Cells, 12 (2023)
Mucin-microbiome signatures shape the tumor microenvironment in gastric cancer.
Oosterlinck, et al.
Microbiome, 11, 86-86 (2023)

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