一般描述
腺瘤性息肉病大肠杆菌蛋白(APC)是一种普遍存在的多结构域蛋白，已被证明具有抑癌作用。APC介导的肿瘤抑制机制仍然是一个积极研究的领域。但是，一些研究表明，APC是Wnt信号通路的负调节剂，因为它通过与Axin/GSK3-β复合物的相互作用来下调β-连环蛋白，从而阻止了有助于细胞增殖的基因（例如MYC）的转录。有缺陷的APC蛋白有助于各种类型的癌症的发生和增殖，包括家族性腺瘤性息肉病。但是，其他研究表明，APC与一系列其他蛋白质（例如EB1微管结合蛋白）相互作用，以调节其他过程（例如细胞迁移）。
免疫原
对应于人APC的重组蛋白。
应用
免疫组织化学分析：一个来自独立实验室的代表性批次在含有多发性硬化症病变的人脑组织中检测到APC（Saikali，P.et al.（2007）.J Neurosci. 27（5）:1220-1228）。
免疫组织化学分析：一个来自独立实验室的代表性批次在大鼠脊髓损伤组织中检测到APC（McTique，D.M.，et al.（2001）.J Neurosci. 21（10）:3392-3400.）。
免疫组织化学分析：一个来自独立实验室的代表性批次在大鼠脊髓损伤组织中检测到APC（McTique，D.M.，et al.（2001）.J Neurosci. 21（10）:3392-3400.）。
抗APC抗体（克隆CC-1）可检测APC蛋白水平，&已发布&验证可用于IHC。
质量
免疫组织化学分析：一个代表性批次以1:5稀释度在人结肠直肠癌组织、人平滑肌组织和人结肠组织中检测到APC。
目标描述
计算分子量311 kDa
外形
形式：纯化
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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