MABC178
Anti-P-Rex1 Antibody, clone 6F12
clone 6F12, from mouse
别名:
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, P-Rex1, PtdIns(3,4,5)-dependent Rac exchanger 1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
6F12, monoclonal
Application:
western blot
Species reactivity:
human
Citations:
4
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
Anti-P-Rex1 Antibody, clone 6F12, clone 6F12, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
6F12, monoclonal
species reactivity
human
technique(s)
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PREX1(57580)
Application
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
This Anti-P-Rex1, clone 6F12 is validated for use in IP, WB, IH for the detection of P-Rex1.
Western Blot Analysis: A representative lot was used by an independent laboratory to detect P-Rex 1 in PC3 cell lysate (Donald, S.,et al., 2010.), bone-marrow-derived neutrophils from mice (Qin, J., et al., 2009.), and mouse brain sections. (Welch, H, et al., 2005.)
Analysis Note
Control
THP-1 cell lysate
THP-1 cell lysate
Evaluated by Western Blot in THP-1 cell lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected P-Rex 1 in 10 µg of THP-1 cell lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected P-Rex 1 in 10 µg of THP-1 cell lysate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1protein (P-Rex1) is a guanine nucleotide exchange factor, which is predominantly expressed in the brain and leucocytes. It exchanges GDP for GTP in Rac 1, resulting in activation of Rac and its downstream signaling molecules that mediate such cellular processes as axon migration and differentiation.
~186 kDa observed
Immunogen
Linear peptide corresponding to human P-Rex 1.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Emanuela Dylgjeri et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(18), 5623-5637 (2019-07-04)
DNA-dependent protein kinase catalytic subunit (DNA-PK) is a pleiotropic kinase involved in DNA repair and transcriptional regulation. DNA-PK is deregulated in selected cancer types and is strongly associated with poor outcome. The underlying mechanisms by which DNA-PK promotes aggressive tumor
Martin J Baker et al.
Cancers, 12(2) (2020-02-26)
The GTPase Rac1 is a well-established master regulator of cell motility and invasiveness contributing to cancer metastasis. Dysregulation of the Rac1 signaling pathway, resulting in elevated motile and invasive potential, has been reported in multiple cancers. However, there are limited
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