Anti-TNFSF13 (APRIL) Antibody, clone A3D8

Tumor necrosis factor ligand superfamily member 13 (UniProt: Q9D777; also known as A proliferation-inducing ligand; APRIL; CD256) is encoded by the Tnfsf13 (also known as APRIL) gene (Gene ID: 69583) in mouse. APRIL is a secreted cytokine of the tumor necrosis family and is present in T cells, B cells, dendritic cells, monocytes, and macrophages. April exists as a functional homotrimer, but can form functional heterotrimers with B cell activating factor (BAFF). APRIL stimulates T and B cell proliferation and it exerts T and B cell regulatory effects by binding to TNFRSF17 (BCMA) and TNFRSF13B (TACI) receptors. It is also involved in monocyte/macrophage-mediated immunological processes. It also plays a role in the regulation of tumor cell growth and can induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. APRIL can serve as as a potential biomarker and its serum levels are shown to be elevated for certain cancers and expression levels elevated in cancer tissues.

Clone A3D8 detects TNFSF13/APRIL in human peripheral blood mononuclear cells (PBMC).

A full length recombinant fusion protein of murine maltose binding protein (MBP) and soluble APRIL.

Detect TNFSF13 using this armenian hamster monoclonal Anti-TNFSF13 (APRIL) antibody, clone A3D8, Cat. No. MABC1031, validated for use in Flow Cytometry.

Flow Cytometry Analysis: 1 µg of this antibody from a representative lot detected TNFSF13 in one million RAW264.7 cells.

Research Category
Apoptosis & Cancer

Evaluated by Flow Cytometry in human PBMC cells.

Flow Cytometry Analysis: 1 µg of this antibody detected TNFSF13 in human PBMC cells.

26.89 kDa calculated.

Protein G purified

Format: Purified

Purified armenian hamster monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Concentration: Please refer to lot specific datasheet.

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