biological source
mouse
antibody form
purified immunoglobulin
clone
1A4B.6, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, immunofluorescence: suitable, inhibition assay: suitable (hemagglutination)
isotype
IgG2b
shipped in
wet ice
Quality Level
Immunogen
Epitope: Virus
Application
Detect the Eastern Equine Encephalitis protein using this Anti-Eastern Equine Encephalitis, Virus, clone 1A4B.6 validated for use in ELISA, IF & Hemagglutination Inhibition.
ELISA
Indirect Immunofluorescence
Hemagglutination Inhibition
Optimal working dilutions must be determined by end user.
Indirect Immunofluorescence
Hemagglutination Inhibition
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
The MAb 1A4B-6 is an IgG2b antibody that reacts with an
E1 epitope shared by all alphaviruses. Encephalitis Virus: Strains Indentified:
Eastern Equine (EEE) N. American eastern equine (NJ/60);
S. American eastern equine (BeAn 5122)
Western Equine (WEE) Western equine (McMIllan); Highlands J (B-230);
Sindbis
Semliki Forest Semliki Forest
Venezuelan Equine (VEE) 1AB (TC-83 Vaccine, Trinidad Donkey, PTF-39);
1C (P676); 1D (3880); 1E ( Mena II);
1F(78V-3531); 2 (Fe3-7c); 3 (Mucambo);
4 (Pixuna); 5 (Cabassou)
E1 epitope shared by all alphaviruses. Encephalitis Virus: Strains Indentified:
Eastern Equine (EEE) N. American eastern equine (NJ/60);
S. American eastern equine (BeAn 5122)
Western Equine (WEE) Western equine (McMIllan); Highlands J (B-230);
Sindbis
Semliki Forest Semliki Forest
Venezuelan Equine (VEE) 1AB (TC-83 Vaccine, Trinidad Donkey, PTF-39);
1C (P676); 1D (3880); 1E ( Mena II);
1F(78V-3531); 2 (Fe3-7c); 3 (Mucambo);
4 (Pixuna); 5 (Cabassou)
Physical form
Format: Purified
Purified immunoglobulin. Liquid in PBS with 0.1% Sodium Azide.
Preparation Note
Maintain at 2 to 8°C for up to 12 months from date of receipt.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
存储类别
12 - Non Combustible Liquids
Marcel Kruchelski Tschá et al.
Virus evolution, 7(2), veab105-veab105 (2022-03-22)
Genomic and epidemiological surveillance are paramount for the discovery of new viruses with the potential to cross species barriers. Here, we present a new member of the genus Alphavirus found in Trichoprosopon and Wyeomia mosquitoes, tentatively named Pirahy virus (PIRAV).
Japanese encephalitis among hospitalized pediatric and adult patients with acute encephalitis syndrome in Hanoi, Vietnam 1995.
Lowry, P W, et al.
The American Journal of Tropical Medicine and Hygiene, 58, 324-329 (1998)
Brandon J Beddingfield et al.
NPJ vaccines, 9(1), 47-47 (2024-02-28)
MVA-based monovalent eastern equine encephalitis virus (MVA-BN-EEEV) and multivalent western, eastern, and Venezuelan equine encephalitis virus (MVA-BN-WEV) vaccines were evaluated in the cynomolgus macaque aerosol model of EEEV infection. Macaques vaccinated with two doses of 5 × 108 infectious units
Matthew S Sutton et al.
Cell, 186(12), 2672-2689 (2023-06-10)
Alphaviruses are RNA viruses that represent emerging public health threats. To identify protective antibodies, we immunized macaques with a mixture of western, eastern, and Venezuelan equine encephalitis virus-like particles (VLPs), a regimen that protects against aerosol challenge with all three
JinZhu Ma et al.
Biotechnology journal, 16(8), e2100008-e2100008 (2021-06-28)
Western equine encephalitis virus (WEEV) causes lethal encephalitis in humans and equines, and it poses a serious public health threat in many countries. Therefore, the development of an efficient vaccine remains an important challenge for the prevention of WEEV infection.
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