推荐产品
生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
8-18C5, monoclonal
种属反应性
rat, mouse
制造商/商品名称
Chemicon®
技术
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
同位素/亚型
IgG1
GenBank登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
mouse ... Mog(17441)
相关类别
一般描述
髓鞘少突胶质细胞糖蛋白(MOG)是多发性硬化症原发性脱髓鞘的关键CNS特异性自身抗原。尽管已经确定了MOG的疾病诱导作用，但其在中枢神经系统中的确切功能仍然不清楚。 MOG是具有单个细胞外Ig可变域（Ig-V）（3、13、14）的I型整合膜蛋白。MOG的氨基酸序列在动物物种中高度保守（>90%），表明其重要的生物学功能。MOG在髓鞘最外层的中枢神经系统以及少突胶质细胞的细胞体和过程中特异性表达。MOG的发育后期表达与髓鞘生成的后期相关，表明MOG在髓鞘的完成、紧实和/或维持中起作用，进一步表明MOG在CNS中具有粘附功能。与MOG′在CNS中可能的粘附作用一致，MOG的同型二聚体形式不仅在与CNS分离后观察到，而且还在原位观察到。
特异性
MOG[髓鞘少突胶质细胞糖蛋白]的膜相关区域。
基于序列相似性，可能与人和牛发生交叉反应。
免疫原
大鼠小脑糖蛋白
表位：该抗体与MOG的细胞外免疫球蛋白V样结构域上存在的不连续表位结合。
应用
抗髓鞘少突胶质细胞糖蛋白(MOG)抗体是一种抗髓鞘少突胶质细胞糖蛋白(MOG)的抗体，用于FC、IC、IH&WB。
研究子类别
神经元&神经胶质标志物
神经元&神经胶质标志物
研究类别
神经科学
神经科学
质量
通过免疫印迹进行了常规评估。
目标描述
28 kDa
外形
形式：纯化
纯化免疫球蛋白
纯化品，溶于0.1 M Tris-甘氨酸, 0.15 M NaCl, pH 7.4和0.05%叠氮化钠
储存及稳定性
自收到之日起，以未稀释的等分试样在2-8°C下可保存长达1年。
分析说明
对照
脑裂解物
脑裂解物
其他说明
浓度：关于批次特定浓度请参见检验报告。
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
GenBank is a registered trademark of United States Department of Health and Human Services
免责声明
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
WGK
WGK 2
Dan Xu et al.
The Journal of experimental medicine, 215(4), 1169-1186 (2018-03-01)
The pathophysiology of drug-resistant pediatric epilepsy is unknown. Flow cytometric analysis of inflammatory leukocytes in resected brain tissues from 29 pediatric patients with genetic (focal cortical dysplasia) or acquired (encephalomalacia) epilepsy demonstrated significant brain infiltration of blood-borne inflammatory myeloid cells
Rong He et al.
Molecular medicine reports, 16(1), 119-126 (2017-05-24)
Fasudil has been demonstrated to possess a protective effect in neural injury; however, its protective effect on convulsive brain injury remains to be assessed. The aim of the present study was to investigate the latent mechanism and effect of fasudil
Prisca S Leferink et al.
Annals of neurology, 86(5), 780-792 (2019-08-23)
Astrocytes have gained attention as important players in neurological disease. In line with their heterogeneous character, defects in specific astrocyte subtypes have been identified. Leukodystrophy vanishing white matter (VWM) shows selective vulnerability in white matter astrocytes, but the underlying mechanisms
Fadi J Najm et al.
Nature biotechnology, 31(5), 426-433 (2013-04-16)
Cell-based therapies for myelin disorders, such as multiple sclerosis and leukodystrophies, require technologies to generate functional oligodendrocyte progenitor cells. Here we describe direct conversion of mouse embryonic and lung fibroblasts to induced oligodendrocyte progenitor cells (iOPCs) using sets of either
Alvaro Cobo-Calvo et al.
Neurology(R) neuroimmunology & neuroinflammation, 6(2), e543-e543 (2019-02-26)
To describe clinical and radiologic features of cranial nerve (CN) involvement in patients with myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) and to assess the potential underlying mechanism of CN involvement using a nonhuman primate (NHP) model. Epidemiologic, clinical, and radiologic features
商品
Derivation and characterization of functional human neural stem cell derived oligodendrocyte progenitor cells (OPCs) that efficiently myelinate primary neurons in culture.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门