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MAB5512

Sigma-Aldrich

抗-Parkin抗体,克隆PRK8

ascites fluid, clone PRK8, Chemicon®

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别名:
Anti-AR-JP, Anti-LPRS2, Anti-PARK2, Anti-PDJ
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

mouse

抗体形式

ascites fluid

抗体产品类型

primary antibodies

克隆

PRK8, monoclonal

种属反应性

human, mouse

制造商/商品名称

Chemicon®

技术

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

同位素/亚型

IgG2b

UniProt登记号

运输

dry ice

靶向翻译后修饰

unmodified

基因信息

human ... PARK2(5071)

特异性

Parkin。单克隆识别的表位在人Parkin的氨基酸399-465之间。该抗体与parkin基因缺失小鼠提取物中的蛋白质无交叉反应性。

免疫原

重组人parkin。

应用

抗Parkin抗体,克隆PRK8是用于IP、WB、IH的抗Parkin抗体。
研究子类别
神经退行性疾病
研究类别
神经科学
蛋白质印迹法:该抗体可检测小鼠脑提取物中约50和约44 kDa的条带。在人脑提取物中,抗体与~50和~46 kDa反应。免疫组织化学

免疫细胞化学

免疫沉淀

最佳工作稀释度必须由最终用户确定。

外形

腹水液。 液体。不含防腐剂。

储存及稳定性

接收后,以未稀释的等分试样在-20°C下保存长达12个月。应避免反复冻/融循环。

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的目录或产品随附的其他公司文件中另有说明,否则我们的产品预期仅用于研究用途,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death.
Huynh, DP; Nguyen, DT; Pulst-Korenberg, JB; Brice, A; Pulst, SM
Experimental neurology null
J Viotti et al.
Oncogene, 33(14), 1764-1775 (2013-05-07)
Gliomas represent the most frequent form of primary brain tumors in adults, the prognosis of which remains extremely poor. Inactivating mutations on the tumor suppressor TP53 were proposed as a key etiological trigger of glioma development. p53 has been recently
Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription.
Duplan, E; Sevalle, J; Viotti, J; Goiran, T; Bauer, C; Renbaum, P; Levy-Lahad, E; Gautier et al.
Journal of Molecular Cell Biology null
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.
da Costa, CA; Sunyach, C; Giaime, E; West, A; Corti, O; Brice, A; Safe, S; Abou-Sleiman et al.
Nature Cell Biology null
Margot Fournier et al.
PloS one, 4(8), e6629-e6629 (2009-08-15)
In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally. Parkin, an ubiquitin-protein ligase that is dysfunctional in autosomal recessive parkinsonism, protects against alpha-synuclein-mediated toxicity in various models.We analyzed the effects of Parkin deficiency

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