biological source
mouse
antibody form
ascites fluid
antibody product type
primary antibodies
clone
PRK8, monoclonal
species reactivity
human, mouse
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG2b
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... PARK2(5071)
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Immunogen
重组人parkin。
Application
抗Parkin抗体，克隆PRK8是用于IP、WB、IH的抗Parkin抗体。
研究子类别
神经退行性疾病
神经退行性疾病
研究类别
神经科学
神经科学
蛋白质印迹法：该抗体可检测小鼠脑提取物中约50和约44 kDa的条带。在人脑提取物中，抗体与~50和~46 kDa反应。免疫组织化学
免疫细胞化学
免疫沉淀
最佳工作稀释度必须由最终用户确定。
免疫细胞化学
免疫沉淀
最佳工作稀释度必须由最终用户确定。
Biochem/physiol Actions
Parkin。单克隆识别的表位在人Parkin的氨基酸399-465之间。该抗体与parkin基因缺失小鼠提取物中的蛋白质无交叉反应性。
Physical form
腹水液。 液体。不含防腐剂。
Preparation Note
接收后，以未稀释的等分试样在-20°C下保存长达12个月。应避免反复冻/融循环。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death.
Huynh, DP; Nguyen, DT; Pulst-Korenberg, JB; Brice, A; Pulst, SM
Experimental neurology null
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.
da Costa, CA; Sunyach, C; Giaime, E; West, A; Corti, O; Brice, A; Safe, S; Abou-Sleiman et al.
Nature Cell Biology null
Fumika Koyano et al.
Genes to cells : devoted to molecular & cellular mechanisms, 18(8), 672-681 (2013-06-12)
PINK1 and PARKIN are causal genes for hereditary Parkinsonism. Recent studies have shown that PINK1 and Parkin play a pivotal role in the quality control of mitochondria, and dysfunction of either protein likely results in the accumulation of low-quality mitochondria
J Viotti et al.
Oncogene, 33(14), 1764-1775 (2013-05-07)
Gliomas represent the most frequent form of primary brain tumors in adults, the prognosis of which remains extremely poor. Inactivating mutations on the tumor suppressor TP53 were proposed as a key etiological trigger of glioma development. p53 has been recently
A Kathrin Lutz et al.
The Journal of biological chemistry, 284(34), 22938-22951 (2009-06-24)
Loss-of-function mutations in the parkin gene (PARK2) and PINK1 gene (PARK6) are associated with autosomal recessive parkinsonism. PINK1 deficiency was recently linked to mitochondrial pathology in human cells and Drosophila melanogaster, which can be rescued by parkin, suggesting that both
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