MAB5502
抗-囊泡谷氨酸转运体1抗体
CHEMICON®, mouse monoclonal, 3C10.2
别名:
Solute carrier family 17 member 7, Brain-specific Na(+)-dependent inorganic phosphate cotransporter, vGluT1
登录 查看组织和合同定价。
选择尺寸
关于此项目
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
3C10.2, monoclonal
Species reactivity:
mouse
Application:
IHC, WB
Citations:
76
产品名称
抗-囊泡谷氨酸转运体1抗体, clone 3C10.2, Chemicon®, from mouse
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3C10.2, monoclonal
species reactivity
mouse
species reactivity (predicted by homology)
rat
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
rat ... Slc17A7(116638)
正在寻找类似产品? 访问 产品对比指南
General description
60 kDa
VGLUT1在谷氨酸神经元的子集中表达，并将谷氨酸从大脑转运到天然突触小泡中，表现出被谷氨酸阻断的氯化物电导。囊泡谷氨酸转运具有比质膜兴奋性氨基酸转运蛋白低得多的表观亲和力。VGLUT1的谷氨酸转运被约2 mM的K(m)饱和，与突触小泡的转运范围相同。最后，质膜谷氨酸转运蛋白将天冬氨酸和谷氨酸都识别为底物，而VGLUT1不识别天冬氨酸。 囊泡谷氨酸转运蛋白将神经递质包装到突触小泡中，以便它们可以释放到突触中。VGLUT依赖于它们通过水解三磷酸腺苷(ATP)产生的质子梯度。VGLUT对谷氨酸的亲和力仅为EAAT的百分之一至千分之一。
Immunogen
来自大鼠VGLUT1的重组蛋白。
Application
免疫组织化学：
通过IH检验了该抗体的一个先前批次。
最佳工作稀释度必须由最终用户确定。
通过IH检验了该抗体的一个先前批次。
最佳工作稀释度必须由最终用户确定。
研究子类别
离子通道&转运蛋白
神经元&神经胶质标志物
离子通道&转运蛋白
神经元&神经胶质标志物
研究类别
神经科学
神经科学
该抗囊泡谷氨酸转运蛋白1抗体，克隆3C10.2，目录号MAB5502，经验证可用于IH、WB检测VGluT1。
Biochem/physiol Actions
与VGLUT1（囊泡谷氨酸转运蛋白1）反应。
Physical form
形式：纯化
纯化的小鼠单克隆IgG1，溶于含0.1%叠氮化钠的PBS的缓冲液中。
纯化蛋白A
Preparation Note
自收到之日起以未稀释的等分试样形式，在2-8ºC可稳定保存6个月。
Analysis Note
对照
脑
VGLUT1对照肽AG208
脑
VGLUT1对照肽AG208
通过蛋白质印迹法对小鼠脑裂解物进行常规评估。
蛋白质印迹分析：
该批次以1:500稀释度在10 μg小鼠脑裂解物中检测到囊泡谷氨酸转运蛋白1。
蛋白质印迹分析：
该批次以1:500稀释度在10 μg小鼠脑裂解物中检测到囊泡谷氨酸转运蛋白1。
Other Notes
浓度：关于批次特定浓度请参见检验报告。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
April P Neal et al.
Toxicological sciences : an official journal of the Society of Toxicology, 116(1), 249-263 (2010-04-09)
Lead (Pb(2+)) exposure is known to affect presynaptic neurotransmitter release in both in vivo and cell culture models. However, the precise mechanism by which Pb(2+) impairs neurotransmitter release remains unknown. In the current study, we show that Pb(2+) exposure during
Kajari Karmakar et al.
Cell reports, 18(1), 185-197 (2017-01-05)
Tonotopy is a hallmark of auditory pathways and provides the basis for sound discrimination. Little is known about the involvement of transcription factors in brainstem cochlear neurons orchestrating the tonotopic precision of pre-synaptic input. We found that in the absence
Differentiation of Spiral Ganglion-Derived Neural Stem Cells into Functional Synaptogenetic Neurons.
Xiaoyang Li et al.
Stem cells and development, 25(10), 803-813 (2016-03-30)
Spiral ganglion neurons (SGNs) are usually damaged in sensorineural hearing loss. SGN-derived neural stem cells (NSCs) have been identified and proposed to differentiate into neurons to replace damaged SGNs. However, it remains obscure whether SGN-NSC-derived neurons (ScNs) are electrophysiologically functional
Olga C Jorge-Torres et al.
Cell reports, 23(6), 1665-1677 (2018-05-10)
Rett syndrome (RTT) is the second leading cause of mental impairment in girls and is currently untreatable. RTT is caused, in more than 95% of cases, by loss-of-function mutations in the methyl CpG-binding protein 2 gene (MeCP2). We propose here
Neta Rosenzweig et al.
Nature communications, 10(1), 465-465 (2019-01-30)
Alzheimer's disease (AD) is a heterogeneous disorder with multiple etiologies. Harnessing the immune system by blocking the programmed cell death receptor (PD)-1 pathway in an amyloid beta mouse model was shown to evoke a sequence of immune responses that lead
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持