MAB5284
Anti-Aggrecan Antibody
CHEMICON®, mouse monoclonal, Cat-301
别名:
CSPG
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关于此项目
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
Cat-301, monoclonal
Species reactivity:
primate, human, rat, gerbil, feline, hamster, guinea pig
Application:
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Citations:
36
Uniprot accession no.:
产品名称
硫酸软骨素蛋白聚糖抗体，脑（核心蛋白），克隆Cat-301, clone Cat-301, Chemicon®, from mouse
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
Cat-301, monoclonal
species reactivity
primate, human, rat, gerbil, feline, hamster, guinea pig
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ACAN(176)
Application
免疫组化：4%多聚甲醛固定的冷冻组织上按1:500-1:2,000。
免疫组化
免疫印迹
免疫沉淀
最佳工作稀释度必须由最终用户确定。
免疫组化
免疫印迹
免疫沉淀
最佳工作稀释度必须由最终用户确定。
硫酸软骨素蛋白聚糖抗体（脑（核心蛋白），克隆Cat-301）可检测硫酸软骨素蛋白聚糖水平& 已发表 & 经验证可用于IP,、WB、IC、IH。
Biochem/physiol Actions
硫酸软骨素蛋白聚糖（CSPG），脑核心蛋白。
General description
克隆CAT-301识别的抗原是一种受发育调控的蛋白聚糖，是存在于哺乳动物神经元细胞外表面的高分子硫酸软骨素蛋白聚糖。它在发育后期表达，尽管尚未确定CAT-301的确切作用，但据信它在突触结构的稳定中起作用。
该名称来源于最初用于通过其表达进行鉴定的单克隆抗体的名称，该抗体通过免疫细胞化学进行检测
在关键的出生早期，通过物理或生化手段破坏神经元活动的正常模式会导致CAT-301水平大幅度不可逆地降低。对成熟动物的类似干预没有作用。
CAT-301与关节软骨中的聚集蛋白聚糖有关。CAT-301抗体可与聚集蛋白聚糖发生免疫反应，软骨素酶处理的聚集蛋白聚糖和CAT-301的表观分子量均为550kDa。但是，CAT-301不会像聚集蛋白聚糖那样被硫酸角质素糖基化。
该名称来源于最初用于通过其表达进行鉴定的单克隆抗体的名称，该抗体通过免疫细胞化学进行检测
在关键的出生早期，通过物理或生化手段破坏神经元活动的正常模式会导致CAT-301水平大幅度不可逆地降低。对成熟动物的类似干预没有作用。
CAT-301与关节软骨中的聚集蛋白聚糖有关。CAT-301抗体可与聚集蛋白聚糖发生免疫反应，软骨素酶处理的聚集蛋白聚糖和CAT-301的表观分子量均为550kDa。但是，CAT-301不会像聚集蛋白聚糖那样被硫酸角质素糖基化。
Immunogen
猫脊髓固定灰质。
表位：脑（核心蛋白）
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Lena Iwai et al.
Cerebral cortex (New York, N.Y. : 1991), 23(9), 2204-2212 (2012-07-14)
Although the parallel visual pathways are a fundamental basis of visual processing, our knowledge of their molecular properties is still limited. Here, we uncovered a parvocellular-specific molecule in the dorsal lateral geniculate nucleus (dLGN) of higher mammals. We found that
Otavio S C Mariani et al.
The Journal of comparative neurology, 527(3), 694-717 (2018-03-27)
We propose a partitioning of the primate intraparietal sulcus (IPS) using immunoarchitectural and connectivity criteria. We studied the immunoarchitecture of the IPS areas in the capuchin monkey using Cat-301 and SMI-32 immunohistochemistry. In addition, we investigated the IPS projections to
Vasily Vorobyov et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(1), 234-243 (2013-01-04)
Monocular deprivation (MD) during a critical period of postnatal development produces significant changes in the anatomy and physiology of the visual cortex, and the deprived eye becomes amblyopic. Extracellular matrix molecules have a major role in restricting plasticity such that
Daniel L Felch et al.
Frontiers in neuroanatomy, 6, 12-12 (2012-04-20)
Previous research has suggested that the three physiologically defined relay cell-types in mammalian lateral geniculate nucleus (LGN)-called parvocellular (P), magnocellular (M), and koniocellular (K) cells in primates and X, Y, and W cells in other mammals-each express a unique combination
Danai Riga et al.
Science translational medicine, 9(421) (2017-12-22)
Patients with depression often suffer from cognitive impairments that contribute to disease burden. We used social defeat-induced persistent stress (SDPS) to induce a depressive-like state in rats and then studied long-lasting memory deficits in the absence of acute stressors in
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