MAB5268
抗-嗜铬粒蛋白A抗体，克隆LK2H10
clone LK2H10, Chemicon®, from mouse
别名:
CgA, Pituitary Secretory Protein I
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
LK2H10, monoclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
western blot
western blot
Species reactivity:
porcine, pig, monkey, rat, human, mouse
Citations:
21
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-嗜铬粒蛋白A抗体，克隆LK2H10, clone LK2H10, Chemicon®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
clone
LK2H10, monoclonal
species reactivity
porcine, pig, monkey, rat, human, mouse
should not react with
guinea pig, rabbit, sheep
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CHGA(1113)
相关类别
Analysis Note
对照
胰腺、肾上腺、肠和甲状腺组织免疫印迹：PC12细胞裂解物，人胰腺组织
胰腺、肾上腺、肠和甲状腺组织免疫印迹：PC12细胞裂解物，人胰腺组织
通过蛋白质印迹法对小鼠胰腺裂解物进行了常规评估。
蛋白质印迹分析：
该批次以1:1000稀释度在10 μg小鼠胰腺裂解物中检测到嗜铬粒蛋白A。
蛋白质印迹分析：
该批次以1:1000稀释度在10 μg小鼠胰腺裂解物中检测到嗜铬粒蛋白A。
Application
使用经验证可用于IH、IH(P)&WB的该抗嗜铬粒蛋白A抗体（克隆LK2H10）检测嗜铬粒蛋白A。
免疫组织化学：
一个先前批次的1-10 μg/mL浓度被用于IH。
最佳工作稀释度必须由最终用户确定。
一个先前批次的1-10 μg/mL浓度被用于IH。
最佳工作稀释度必须由最终用户确定。
Biochem/physiol Actions
嗜铬粒蛋白是一种分子量约为68kDa的酸性蛋白，存在于人内分泌组织的含有多肽-激素的分泌颗粒中。 抗嗜铬粒蛋白A可用于染色大多数含有分泌颗粒的正常和肿瘤性内分泌组织（例外情况包括来自下丘脑和垂体后叶的细胞，已知它们含有分泌颗粒）。染色量通常与存在的分泌颗粒数量成正比（1）。
General description
嗜铬粒蛋白A（一种由439个氨基酸组成的蛋白质，在14号染色体上编码）存在于全身的神经内分泌细胞中，包括大小肠、肾上腺髓质和胰岛的神经内分泌细胞。它是类癌、表嗜铬细胞瘤、副神经节瘤和其他神经内分泌肿瘤的极佳标志物。嗜铬粒蛋白A和神经元特异性烯醇化酶(NSE)的共表达在神经内分泌肿瘤中很常见。
50 kDa
Other Notes
替代：CBL219
浓度：关于批次特定浓度请参见检验报告。
Packaging
500 μL
Physical form
形式：纯化
纯化小鼠单克隆IgG1，溶于含0.05 M硼酸盐缓冲液、0.15 M NaCl（pH 8.2）和0.1%叠氮化钠的缓冲液中。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Repr. 1B
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Tieying Hou et al.
Cancer cytopathology, 128(10), 725-732 (2020-06-24)
Insulinoma-associated protein 1 (INSM1) has recently emerged as a reliable nuclear immunostaining marker for detecting neuroendocrine tumors (NETs) in paraffin-embedded surgical samples and cytologic cell blocks, but the reliability of INSM1 staining on cytologic smears is understudied. This study investigated
Fausto J Rodriguez et al.
Brain pathology (Zurich, Switzerland), 19(4), 623-629 (2008-08-20)
Co-deletion of chromosome arms 1p and 19q, characteristic of oligodendroglial tumors, was recently found to be mediated by t(1;19)(q10;p10). To evaluate the prevalence of 1p19q co-deletion and t(1;19) in extraventricular neurocytomas (EVN), we studied tumors from 23 patients, including 13
Neuron precursor features of spindle cell oncocytoma of adenohypophysis.
Sanda Alexandrescu,Robert E Brown,Nitin Tandon,Meenakshi B Bhattacharjee
Annals of Clinical and Laboratory Science null
Specific endocrine tissue marker defined by a monoclonal antibody.
Lloyd, R V and Wilson, B S
Science (New York, N.Y.), 222, 628-630 (1983)
Malin Grönberg et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 56(9), 793-801 (2008-05-14)
Obestatin and ghrelin are two peptides derived from the same prohormone. It is well established that ghrelin is produced by endocrine cells in the gastric mucosa. However, the distribution of human obestatin immunoreactive cells is not thoroughly characterized. A polyclonal
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