Anti-Survivin Antibody, clone 8E2

Survivin, an inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin′s anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.

MAB4617 detects human survivin (16.5 kDa).

Full length recombinant human survivin

Detect Survivin using this Anti-Survivin Antibody, clone 8E2 validated for use in ELISA & IF.

Immunofluorescence

ELISA (for detection only)

Does not work for Western Blot

Does not work for Immunohistochemistry

Optimal working dilutions must be determined by end user.

Research Category
Apoptosis & Cancer

Research Sub Category
BCL2 & Inhibition

Replaces: MAB3509

Format: Purified

Purified immunoglobulin, by Protein G. Liquid in 10 mM PBS, pH 7,4 containing 0.2% BSA and 0.09% sodium azide.

Maintain at 2-8°C for up to 12 months.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.