MAB4418
抗-无刚毛鳞甲同系物2抗体，克隆7E2
clone 7E2, from mouse
别名:
achaete-scute complex (Drosophila) homolog-like 2, achaete-scute complex homolog 2 (Drosophila), achaete-scute complex homolog-like 2, achaete-scute complex-like 2, achaete-scute complex-like 2 (Drosophila), mammalian achaete/scute homologue 2
产品名称
抗-无刚毛鳞甲同系物2抗体，克隆7E2, clone 7E2, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
7E2, monoclonal
species reactivity
human
technique(s)
ChIP: suitable
immunocytochemistry: suitable
western blot: suitable
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ASCL2(430)
Analysis Note
通过蛋白质印迹法在人胎盘组织裂解物中进行评价。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg人胎盘组织裂解物上检测到Achaete Scute同系物2。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg人胎盘组织裂解物上检测到Achaete Scute同系物2。
Application
免疫细胞化学分析： 一个先前批次被独立实验室用于IC（Van de Flier，L.G.，et al.，2009）
染色质免疫沉淀分析： 一个先前批次被独立实验室用于ChIP（Hatzis，P.，et al.，2008）。
染色质免疫沉淀分析： 一个先前批次被独立实验室用于ChIP（Hatzis，P.，et al.，2008）。
抗Achaete Scute同系物2抗体，克隆7E2检测Achaete Scute同系物2的水平，&已发布&验证可用于WB、IC、ChIP。
Biochem/physiol Actions
该抗体识别C末端附近的Achaete Scute同系物2。
General description
Achaete Scute同系物2（也称为哺乳动物无刚毛鳞甲同系物2或Mash2）是在发育中的胎盘的绒毛外滋养细胞中特异性表达的核蛋白。胎盘发育涉及基本螺旋-环-螺旋转录因子Achaete Scute同系物2的控制，其可以调节海绵滋养细胞形成中的HIF（缺氧）。Achaete Scute同系物2的定向诱变产生功能丧失导致妊娠中期胚胎致死，这是由于胎盘衰竭与海绵滋养细胞缺乏和迷宫滋养细胞层减少有关。除了健康的胎盘发育外，Achaete Scute蛋白还可能参与中枢和周围神经系统神经元前体的测定。Achaete Scute同系物2也被认为是肠干细胞命运的控制者，并且是维持成人肠干细胞所必需的（Tanaka，M.，et al.，（1997）Dev Biol. 190（10）:55-65）。
约20 kDa
Immunogen
His标记的重组蛋白，对应于C末端附近的人Achaete Scute同系物2。
Other Notes
浓度：关于批次特定浓度请参见检验报告。
Physical form
形式：纯化
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Jun Ye et al.
Cell cycle (Georgetown, Tex.), 17(8), 1014-1025 (2018-06-12)
The Wnt signaling pathway controls stem cell identity in the intestinal epithelium and cancer stem cells (CSCs). The transcription factor Ascl2 (Wnt target gene) is fate decider of intestinal cryptic stem cells and colon cancer stem cells. It is unclear
Yangyang Shang et al.
Oncotarget, 6(31), 30993-31006 (2015-08-27)
The role of Achaete scute-like 2 (Ascl2) in colorectal cancer (CRC) cell differentiation is unknown. LS174T, HT-29 and Caco-2 cells have high Ascl2 expression, while Lovo and SW480 cells have low Ascl2 expression. LS174T and HT-29 cells with Ascl2 knockdown
Zhuo Ma et al.
Nature communications, 14(1), 5354-5354 (2023-09-03)
Understanding pancreas development can provide clues for better treatments of pancreatic diseases. However, the molecular heterogeneity and developmental trajectory of the early human pancreas are poorly explored. Here, we performed large-scale single-cell RNA sequencing and single-cell assay for transposase accessible
Jarom Heijmans et al.
Cell reports, 3(4), 1128-1139 (2013-04-03)
Stem cells generate rapidly dividing transit-amplifying cells that have lost the capacity for self-renewal but cycle for a number of times until they exit the cell cycle and undergo terminal differentiation. We know very little of the type of signals
Genta Nagae et al.
Nature communications, 12(1), 5423-5423 (2021-09-21)
Hepatoblastoma (HB) is the most common pediatric liver malignancy; however, hereditary predisposition and acquired molecular aberrations related to HB clinicopathological diversity are not well understood. Here, we perform an integrative genomic profiling of 163 pediatric liver tumors (154 HBs and
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