MAB4417
抗-无刚毛鳞甲同系物2抗体，克隆8F1
clone 8F1, from mouse
别名:
achaete-scute complex (Drosophila) homolog-like 2, achaete-scute complex homolog 2 (Drosophila), achaete-scute complex homolog-like 2, achaete-scute complex-like 2, achaete-scute complex-like 2 (Drosophila), mammalian achaete/scute homologue 2
产品名称
抗-无刚毛鳞甲同系物2抗体，克隆8F1, clone 8F1, from mouse
Quality Level
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
8F1, monoclonal
species reactivity
human
species reactivity (predicted by homology)
mouse (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ASCL2(430)
Analysis Note
通过蛋白质印迹法在人胎盘组织裂解物中进行评价。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg人胎盘组织裂解物上检测到Achaete Scute同系物2。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg人胎盘组织裂解物上检测到Achaete Scute同系物2。
Application
免疫组织化学：该抗体的一个先前批次由独立实验室用于免疫细胞化学（Van der Flier，et al.，2009）。
抗Achaete Scute同系物2抗体，克隆8F1是针对Achaete Scute同系物2的抗体，用于WB、IH。
Biochem/physiol Actions
该抗体识别Achaete Scute同系物2。
General description
Achaete Scute同系物2（也称为哺乳动物无刚毛鳞甲同系物2或Mash2）是在发育中的胎盘的绒毛外滋养细胞中特异性表达的核蛋白。胎盘发育涉及基本螺旋-环-螺旋转录因子Achaete Scute同系物2的控制，其可以调节海绵滋养细胞形成中的HIF（缺氧）。Achaete Scute同系物2的定向诱变产生功能丧失导致妊娠中期胚胎致死，这是由于胎盘衰竭与海绵滋养细胞缺乏和迷宫滋养细胞层减少有关。除了健康的胎盘发育外，Achaete Scute蛋白还可能参与中枢和周围神经系统神经元前体的测定。Achaete Scute同系物2也被认为是肠干细胞命运的控制者，并且是维持成人肠干细胞所必需的（Tanaka，M.，et al.，（1997）Dev Biol. 190（10）:55-65）。
约20 kDa
Immunogen
His标记的重组蛋白，对应于小鼠Achaete Scute同系物2。
Other Notes
浓度：关于批次特定浓度请参见检验报告。
Physical form
形式：纯化
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Jie Wang et al.
Oncotarget, 9(34), 23320-23333 (2018-05-29)
Achaete-scute-like 2 (ASCL2) is a transcription factor containing a basic helix-loop-helix (bHLH) domain and is a downstream target of Wnt signaling in intestinal stem cells. Bufalin is the primary active ingredient in Chan Su, a traditional Chinese medicine obtained from
Qingyu Wang et al.
Stem cell reports, 15(2), 374-388 (2020-07-11)
Intestinal regeneration is crucial for functional restoration after injury, and nutritional molecules can play an important role in this process. Here, we found that arachidonic acid (AA) serves as a direct proliferation promoter of intestinal epithelial cells that facilitates small
Rosemary Oh-McGinnis et al.
Developmental biology, 351(2), 277-286 (2011-01-18)
Several imprinted genes have been implicated in the regulation of placental function and embryonic growth. On distal mouse chromosome 7, two clusters of imprinted genes, each regulated by its own imprinting center (IC), are separated by a poorly characterized region
Justine Creff et al.
Cell reports, 42(6), 112659-112659 (2023-06-16)
p57Kip2 is a cyclin/CDK inhibitor and a negative regulator of cell proliferation. Here, we report that p57 regulates intestinal stem cell (ISC) fate and proliferation in a CDK-independent manner during intestinal development. In the absence of p57, intestinal crypts exhibit
Kevin C Allan et al.
Cell stem cell, 28(2), 257-272 (2020-10-23)
Mammalian cells respond to insufficient oxygen through transcriptional regulators called hypoxia-inducible factors (HIFs). Although transiently protective, prolonged HIF activity drives distinct pathological responses in different tissues. Using a model of chronic HIF1a accumulation in pluripotent-stem-cell-derived oligodendrocyte progenitors (OPCs), we demonstrate
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