所有图片(1)
别名:
achaete-scute complex (Drosophila) homolog-like 2, achaete-scute complex homolog 2 (Drosophila), achaete-scute complex homolog-like 2, achaete-scute complex-like 2, achaete-scute complex-like 2 (Drosophila), mammalian achaete/scute homologue 2
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
8F1, monoclonal
种属反应性
human
种属反应性（根据同源性预测）
mouse (based on 100% sequence homology)
技术
immunohistochemistry: suitable
western blot: suitable
同位素/亚型
IgG1κ
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... ASCL2(430)
一般描述
Achaete Scute同系物2（也称为哺乳动物无刚毛鳞甲同系物2或Mash2）是在发育中的胎盘的绒毛外滋养细胞中特异性表达的核蛋白。胎盘发育涉及基本螺旋-环-螺旋转录因子Achaete Scute同系物2的控制，其可以调节海绵滋养细胞形成中的HIF（缺氧）。Achaete Scute同系物2的定向诱变产生功能丧失导致妊娠中期胚胎致死，这是由于胎盘衰竭与海绵滋养细胞缺乏和迷宫滋养细胞层减少有关。除了健康的胎盘发育外，Achaete Scute蛋白还可能参与中枢和周围神经系统神经元前体的测定。Achaete Scute同系物2也被认为是肠干细胞命运的控制者，并且是维持成人肠干细胞所必需的（Tanaka，M.，et al.，（1997）Dev Biol. 190（10）:55-65）。
特异性
该抗体识别Achaete Scute同系物2。
免疫原
His标记的重组蛋白，对应于小鼠Achaete Scute同系物2。
应用
免疫组织化学：该抗体的一个先前批次由独立实验室用于免疫细胞化学（Van der Flier，et al.，2009）。
抗Achaete Scute同系物2抗体，克隆8F1是针对Achaete Scute同系物2的抗体，用于WB、IH。
质量
通过蛋白质印迹法在人胎盘组织裂解物中进行评价。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg人胎盘组织裂解物上检测到Achaete Scute同系物2。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg人胎盘组织裂解物上检测到Achaete Scute同系物2。
目标描述
约20 kDa
外形
形式：纯化
其他说明
浓度：关于批次特定浓度请参见检验报告。
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Qingyu Wang et al.
Stem cell reports, 15(2), 374-388 (2020-07-11)
Intestinal regeneration is crucial for functional restoration after injury, and nutritional molecules can play an important role in this process. Here, we found that arachidonic acid (AA) serves as a direct proliferation promoter of intestinal epithelial cells that facilitates small
Jie Wang et al.
Oncotarget, 9(34), 23320-23333 (2018-05-29)
Achaete-scute-like 2 (ASCL2) is a transcription factor containing a basic helix-loop-helix (bHLH) domain and is a downstream target of Wnt signaling in intestinal stem cells. Bufalin is the primary active ingredient in Chan Su, a traditional Chinese medicine obtained from
Rosemary Oh-McGinnis et al.
Developmental biology, 351(2), 277-286 (2011-01-18)
Several imprinted genes have been implicated in the regulation of placental function and embryonic growth. On distal mouse chromosome 7, two clusters of imprinted genes, each regulated by its own imprinting center (IC), are separated by a poorly characterized region
Kevin C Allan et al.
Cell stem cell, 28(2), 257-272 (2020-10-23)
Mammalian cells respond to insufficient oxygen through transcriptional regulators called hypoxia-inducible factors (HIFs). Although transiently protective, prolonged HIF activity drives distinct pathological responses in different tissues. Using a model of chronic HIF1a accumulation in pluripotent-stem-cell-derived oligodendrocyte progenitors (OPCs), we demonstrate
Yin Tian et al.
The Journal of biological chemistry, 289(52), 36101-36115 (2014-11-06)
Ascl2, a basic helix-loop-helix transcription factor, is a downstream target of WNT signaling that controls the fate of intestinal cryptic stem cells and colon cancer progenitor cells. However, its involvement in colon cancer and downstream molecular events is largely undefined;
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