生物来源
mouse
质量水平
抗体形式
tissue culture supernatant
抗体产品类型
primary antibodies
克隆
MRPm5, monoclonal
种属反应性
human
制造商/商品名称
Chemicon®
技术
flow cytometry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
同位素/亚型
IgG2a
UniProt登记号
运输
dry ice
基因信息
human ... ABCC1(4363)
特异性
This antibody reacts with an internal epitope of MRP1, a 180-195 kDa transmembrane transporter protein overexpressed in various human non-P-glycoprotein MDR tumor cell lines. The antibody does not cross-react with the human MDR1 and MDR3 gene products.
免疫原
Bacterial fusion protein of MRP1 containing amino acids 986-1204 of the protein.
应用
Detect MRP1 using this Anti-MRP1 Antibody, clone MRPm5 validated for use in FC, WB, IH, IH(P).
Research Category
Metabolism
Metabolism
Research Sub Category
Toxicology & Drug Resistance
Toxicology & Drug Resistance
Western blotting
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections or paraffin-embedded tissue sections
Flow Cytometry
Optimal working dilutions must be determined by end user.
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections or paraffin-embedded tissue sections
Flow Cytometry
Optimal working dilutions must be determined by end user.
外形
Format: Purified
Purified from tissue culture supernatant, serum-free. Liquid containing 0.7% BSA and 0.1% sodium azide.
储存及稳定性
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze-thaw cycles.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer.
Annals of Oncology, 7, 75-81 (1996)
Prognostic significance of the immunohistochemical expression of O(6)-methylguanine-DNA methyltransferase, P-glycoprotein, and multidrug resistance protein-1 in glioblastomas.
Neuropathology : Official Journal of the Japanese Society of Neuropathology null
Tissue distribution of the multidrug resistance protein.
The American Journal of Pathology, 148, 1237-1247 (1996)
Pharmaceutical research, 28(12), 3091-3100 (2011-08-20)
To explore whether miR-19 is involved in the regulation of multidrug resistance (MDR), one of the main causes of breast cancer mortality, and modulates sensitivity of tumor cells to chemotherapeutic agents. We analyzed miRNA expression levels in three MDR cell
Biochemical pharmacology, 79(6), 817-824 (2009-11-04)
Multidrug resistance-associated protein (MRP-1/ABCC1) transports a wide range of therapeutic agents and may play a critical role in the development of multidrug resistance (MDR) in tumor cells. However, the regulation of MRP-1 remains controversial. To explore whether miRNAs are involved
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