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生物来源
mouse
质量水平
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
P3 II-26, monoclonal
种属反应性
human
制造商/商品名称
Chemicon®
技术
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
同位素/亚型
IgG2b
适用性
not suitable for immunohistochemistry (Paraffin)
UniProt登记号
运输
wet ice
基因信息
human ... ABCB4(5244)
特异性
This antibody reacts with an internal epitope of MDR3 P-gp. It does not cross-react with the human MDR1 P-gp. It has been reported that this clone also cross reacts with mouse MDR2 Pgp {Kok et al 2003 {http://www.biochemj.org/bj/369/0539/3690539.pdf}.
免疫原
Mab was selected after immunization with a fusion protein consisting of Gluthatione-S-Transferase and a fragment of MDR3 P-gp comprising aa 629-692.
应用
Anti-MDR3 Antibody, clone P3 II-26 is an antibody against MDR3 for use in WB, IC, IH.
Western Blotting: MDR3 is a 140 kDa protein.
Immunocytochemistry: 1:20 - 1:50 on acetone-fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone-fixed frozen sections
Not suitable for paraffin-embedded tissues
Optimal working dilutions must be determined by end user.
Immunocytochemistry: 1:20 - 1:50 on acetone-fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone-fixed frozen sections
Not suitable for paraffin-embedded tissues
Optimal working dilutions must be determined by end user.
储存及稳定性
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
G J Hooiveld et al.
Gastroenterology, 117(3), 678-687 (1999-08-28)
Biliary cholesterol secretion is coupled to that of phospholipids in a process controlled by mdr2 P-glycoprotein activity and bile salt secretion. Statins, the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have been shown to affect hepatobiliary lipid secretion in rats. The aim
Tineke Kok et al.
The Biochemical journal, 369(Pt 3), 539-547 (2002-10-17)
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that controls expression of genes involved in lipid metabolism and is activated by fatty acids and hypolipidaemic fibrates. Fibrates induce the hepatic expression of murine multidrug resistance 2 ( Mdr2 )
G L Scheffer et al.
Cancer research, 60(18), 5269-5277 (2000-10-04)
Tumor cells may display a multidrug resistance phenotype by overexpression of ATP binding cassette transporter genes such as multidrug resistance (MDR) 1 P-glycoprotein (P-gp) or the multidrug resistance protein 1 (MRP1). MDR3 P-gp is a close homologue of MDR1 P-gp
Maria Paprocka et al.
European journal of haematology, 99(5), 415-422 (2017-08-15)
It is well established that expression of multi-drug resistance (MDR) proteins (MDR1, BCRP, MDR3, MRP1, and LRP) in leukemic blasts correlates with acute myeloid leukemia (AML) patients' clinical response. Assuming that leukemic stem cells (LSC) are resistant to chemotherapy and
Denis A Evseenko et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 290(5), R1357-R1365 (2005-12-03)
ATP-binding cassette (ABC) efflux transporters are expressed in the human placenta where they are thought to help protect the fetus from xenobiotics. To evaluate models for analysis of ABC transporter function and regulation in the placenta, we have characterized the
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