推荐产品
生物来源
mouse
质量水平
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
MRPm6, monoclonal
种属反应性
human
制造商/商品名称
Chemicon®
技术
flow cytometry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
同位素/亚型
IgG1
UniProt登记号
运输
wet ice
基因信息
human ... ABCC1(4363)
特异性
MRPm6 reacts with an internal epitope of MRP, a 180-195 kDa transmembrane transporter protein overexpressed in various human non-P-glycoprotein MDR tumor cell lines. MRPm6 was raised against a bacterial fusion protein of MRP, containing a segment of 170 amino acids in the carboxy terminal end and part of the carboxy proximal nucleotide binding domain of the protein. MRPm6 does not cross-react with the human MDR1 and MDR3 gene products (Flens et al., 1994).
应用
Anti-Multi-Drug Resistance Related Protein Antibody, clone MRPm6 is an antibody against Multi-Drug Resistance Related Protein for use in FC, WB, IH(P).
Western blot
Flow Cytometry
Immunohistochemistry on frozen and paraffin embedded tissue
sections: 1:20.
Note: For cellular detection permeabilization is required.
Optimal working dilutions must be determined by end user.
Flow Cytometry
Immunohistochemistry on frozen and paraffin embedded tissue
sections: 1:20.
Note: For cellular detection permeabilization is required.
Optimal working dilutions must be determined by end user.
外形
Tissue Culture Supernatant. Liquid containing 0.1% sodium azide and 0.7% BSA.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
M L Den Boer et al.
Leukemia, 11(7), 1078-1085 (1997-07-01)
The clinical relevance of multidrug resistance (MDR)-related proteins in childhood acute lymphoblastic leukemia (ALL) is largely unknown. The diversity of techniques, fixation methods, storage of cells (fresh or cryopreserved) etc, may contribute to discrepancies observed between several studies. We therefore
D Schadendorf et al.
The American journal of pathology, 147(6), 1545-1552 (1995-12-01)
Melanoma cells often display a multidrug-resistant phenotype, but the mechanisms involved are largely unknown. We have studied here the recently identified transport-associated proteins, MRP and LRP, and the well-known drug resistance marker P-glycoprotein using a panel of 16 human melanoma
Tissue distribution of the multidrug resistance protein.
Flens, M J, et al.
The American Journal of Pathology, 148, 1237-1247 (1996)
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