biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
monoclonal
species reactivity
human, mouse
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, immunocytochemistry: suitable, western blot: suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... PPARA(5465)
General description
过氧化物酶体增殖物激活受体（PPAR）是核激素受体，可以被多种化合物激活，包括原纤维、噻唑烷二酮、前列腺素和脂肪酸。已经描述了三种PPAR亚型，称为PPARα、PPARβ（也称为PPARδ）和PPARγ。PPAR通过与类固醇受体的类视黄醇X受体(RXR)家族成员形成异二聚体并与称为PPAR反应元件(PPRE)的特定DNA基序结合来促进转录。PPARα在原代肝细胞中含量很高，它调节参与脂肪酸代谢的蛋白质的表达。PPARβ是分布最广泛的亚型，通常以高水平表达。PPARγ主要存在于脂肪组织中，在调节脂肪细胞分化中起关键作用。
Immunogen
来自小鼠PPARalpha氨基酸18-34的合成肽。
Application
研究类别
表观遗传学&核功能
表观遗传学&核功能
使用经ELISA、WB、ICC验证的抗PPAR α抗体（小鼠单克隆抗体）检测PPAR alpha，也称为过氧化物酶体增殖物激活受体α。
研究子类别
转录因子
转录因子
蛋白质印迹：1:500-1:5000
免疫细胞化学：1:500-1:5000
ELISA：1:500-1:5,000
最佳工作稀释度必须由最终用户确定。
免疫细胞化学：1:500-1:5000
ELISA：1:500-1:5,000
最佳工作稀释度必须由最终用户确定。
Biochem/physiol Actions
与过氧化物酶体增殖物激活受体α（PPARalpha）反应。与PPARbeta或PPARgamma无交叉反应。
Physical form
腹水液。 液体。不含防腐剂。
Preparation Note
接收后，以未稀释的等分试样在-20°C下保存长达6个月。应避免反复冻/融循环。
Analysis Note
对照
3T3全细胞裂解物
3T3全细胞裂解物
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Hao-Yu Liu et al.
Frontiers in nutrition, 8, 711398-711398 (2021-11-02)
Scope: Disruptions of circadian rhythm cause metabolic disorders and are closely related to dietary factors. In this study, we investigated the interplays between the dietary conjugated linoleic acid (CLA)-induced hepatic steatosis and the circadian clock regulation, in association with lipid
Demin Cai et al.
Journal of cellular physiology, 236(6), 4387-4402 (2020-11-14)
Nonalcoholic-fatty-liver-disease (NAFLD) is the result of imbalances in hepatic lipid partitioning and is linked to dietary factors. We demonstrate that conjugated linoleic acid (CLA) when given to mice as a dietary supplement, induced an enlarged liver, hepatic steatosis, and increased
Bo Li et al.
Journal of molecular endocrinology, 53(3), 393-403 (2014-10-15)
The prevalence of non-alcoholic fatty liver disease (NAFLD), a condition characterized by an excessive accumulation of triglycerides (TGs) in hepatocytes, has dramatically increased globally during recent decades. MicroRNAs (miRs) have been suggested to play crucial roles in many complex diseases
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| MAB3890 | 04053252266041 |