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主要文件

MAB3418B

Sigma-Aldrich

Anti-MAP2 Antibody, clone AP20, Biotin Conjugated

clone AP20, from mouse, biotin conjugate

别名:

Microtubule-associated protein 2, MAP-2, MAP2

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

mouse

质量水平

偶联物

biotin conjugate

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

AP20, monoclonal

种属反应性

rat

种属反应性(根据同源性预测)

bovine (immunogen homology), mouse (based on 100% sequence homology), chicken (based on 100% sequence homology), human (based on 100% sequence homology)

技术

immunocytochemistry: suitable

同位素/亚型

IgG

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

chicken ... Map2(424001)
human ... MAP2(4133)
mouse ... Map2(17756) , Map2(281294)
rat ... Map2(25595)

一般描述

The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin, stabilizes microtubules (Herzog and Weber, 1978), and is an excellent marker for neurons. MAP-2 is essential for the development and maintenance of neuronal morphology (Matus, 1991). Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurours. (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules.

免疫原

Bovine brain microtubule protein

应用

Anti-MAP2 Antibody, clone AP20, Biotin Conjugated is an antibody against MAP2 for use in ICC.
Immunocytochemistry Analysis: A 1:25 dilution from a representative lot detected MAP2 in rat E18 primary cortex cells.

质量

Evaluated by Immunohistochemistry in rat cortex tissue.

Immunohistochemistry Analysis: A 1:25 dilution of this antibody detected MAP2 in rat cortex tissue.

目标描述

The unconjugated parent antibody (Cat. No. MAB3418) has an observed molecular weight at ~230 kDa

外形

Purified mouse monoclonal IgG conjugated to Biotin in PBS with 0.1% sodium azide and 15 mg/mL BSA.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Scott D Bury et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(19), 8597-8606 (2002-09-28)
In humans and other animals, sufficient unilateral damage to the sensorimotor cortex can cause impairments in the opposite forelimb and the development of a hyper-reliance on the nonimpaired limb. This hyper-reliance is adaptive to the extent that it contributes to

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