MAB3318
抗-TIMP-3抗体（克隆136-13H4）
clone 136-13H4, Chemicon®, from mouse
别名:
Tissue Inhibitor of Metalloproteinase-3
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
136-13H4, monoclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
rabbit, human
Citations:
18
Technique(s):
immunohistochemistry: suitable (paraffin)
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-TIMP-3抗体（克隆136-13H4）, clone 136-13H4, Chemicon®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
136-13H4, monoclonal
species reactivity
rabbit, human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TIMP3(7078)
Analysis Note
对照
乳腺癌组织
乳腺癌组织
Application
免疫印迹：2 ug/mL
免疫组织化学（石蜡）：10ug/mL
免疫组织化学（冷冻）：2 ug/mL
免疫组织化学（石蜡）：10ug/mL
免疫组织化学（冷冻）：2 ug/mL
抗-TIMP-3 抗体（a.a. 170-188，克隆136-13H4）是一种针对TIMP-3的抗体，可用于 IH（P） & WB。
研究子类别
MMPs & TIMPs
MMPs & TIMPs
研究类别
细胞结构
细胞结构
Biochem/physiol Actions
与人TIMP-3发生特异性反应。 这是人组织抑制剂金属蛋白酶3（人TIMP-3）上的SWYRGWAPPDKSIINATDP的寡肽（残基170-188）的纯化鼠单克隆抗体。
MAB3318 与TIMP-3发生交叉反应，但是不与人TIMP-1 和人TIMP-2反应。
MAB3318 与TIMP-3发生交叉反应，但是不与人TIMP-1 和人TIMP-2反应。
Disclaimer
由Daiichi Fine Chemical Co., Ltd生产
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
26kda
Immunogen
人组织抑制剂金属蛋白酶3上的SWYRGWAPPDKSIINATDP的寡肽（残基170-188）
表位：a.a.170-188
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
液体溶于0.1 M磷酸钠缓冲液，pH值7.0，含有2%无蛋白酶的牛血清白蛋白。
纯化蛋白A
Preparation Note
自收到之日起在-20°C可稳定保存1年。避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始小瓶进行离心。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Lluis Catasus et al.
Histopathology, 62(4), 632-641 (2013-02-06)
Expression of tissue inhibitor of metalloproteinases-3 (TIMP-3) has been found to be decreased in several types of cancer by promoter gene hypermethylation. However, little is known regarding the silencing effect of TIMP3 promoter hypermethylation on gene and protein expression in
S Jane Darnton et al.
International journal of cancer, 115(3), 351-358 (2005-02-03)
Amongst involvement in diverse physiological and pathological processes, TIMP-3 may have an important role in tumour development, growth and metastasis by interaction with metalloproteases in the extracellular matrix. We studied the role and prognostic effect of TIMP-3 in esophageal adenocarcinoma
Chun-Wen Su et al.
Cell death & disease, 10(11), 793-793 (2019-10-19)
The tissue inhibitor of metalloproteinase-3 (TIMP3) is the only member of the TIMP family that binds to the extracellular matrix and suppresses cancer cell growth, angiogenesis, migration, and invasion. However, whether the abnormal expression and promoter methylation of TIMP3 facilitates
Qinglei Li et al.
Reproduction (Cambridge, England), 128(5), 555-564 (2004-10-29)
The matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are potential regulators of the focalized extracellular matrix degradation required for ovulation. The objectives of the present study were to determine localization and temporal regulation of TIMP-3 and TIMP-4 mRNA and
Bartlomiej Perek et al.
BioMed research international, 2013, 730721-730721 (2013-10-24)
Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The aim of this study was to identify any associations between expression of MMP-2 or endogenous tissue
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