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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
VI-26, monoclonal
Application:
ELISA
immunohistochemistry
immunohistochemistry
Species reactivity:
human, rabbit
Citations:
28
Technique(s):
ELISA: suitable
immunohistochemistry: suitable (paraffin)
immunohistochemistry: suitable (paraffin)
Uniprot accession no.:
产品名称
抗VI型胶原抗体,克隆VI-26, clone VI-26, Chemicon®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
VI-26, monoclonal
species reactivity
human, rabbit
should not react with
rat
manufacturer/tradename
Chemicon®
availability
not available in Japan
technique(s)
ELISA: suitable
immunohistochemistry: suitable (paraffin)
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... COL6A1(1291)
Other Notes
浓度:请参考批次特异性浓缩物的分析证书。
Physical form
形式:纯化
液体溶于0.1 M磷酸钠缓冲液,pH值7.0含有2%无蛋白酶的牛血清白蛋白。
纯化的蛋白 A
Analysis Note
对照
睾丸,结缔组织
睾丸,结缔组织
Application
丙酮固定石蜡包埋组织的免疫组化。不建议福尔马林固定。 抗原回收在非特异性过氧化物酶阻断前用0.04%胰蛋白酶在0.01 M CaCl(2)0.05 M Tris-HCL pH值7.6,37°C中处理10分钟。
EIA
最佳工作稀释度必须由最终用户确定。
EIA
最佳工作稀释度必须由最终用户确定。
已发表抗VI型胶原抗体,克隆VI-26可检测VI&型胶原水平,&经验证可用于ELISA,IH(P)。
研究子类别
ECM 蛋白
ECM 蛋白
研究类别
细胞结构
细胞结构
Biochem/physiol Actions
与hCL(VI)发生特异性反应。 这是抗人VI型胶原的纯化小鼠单克隆抗体。VI-26不与变性或还原的VI型胶原反应,尽管该抗体确实识别由α1(VI),α2(VI)α3(γ)组成的三螺旋。 表位尚未定位,并且已知单克隆抗体在天然测定中不会与胶原I、II、III、IV或V反应。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Preparation Note
自发运之日起在-20°C可保存1年。等分以避免反复冻融。为了最大程度地回收产品,在融化后和取下盖子之前,将原始样品瓶进行离心。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Tiziana Triulzi et al.
PloS one, 8(2), e56761-e56761 (2013-02-27)
We recently showed that differential expression of extracellular matrix (ECM) genes delineates four subgroups of breast carcinomas (ECM1, -2, -3- and -4) with different clinical outcome. To further investigate the characteristics of ECM signature and its impact on tumor progression
D O Visscher et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 107(5), 1711-1721 (2018-11-02)
The aim of this study was to design and manufacture an easily assembled cartilage implant model for auricular reconstruction. First, the printing accuracy and mechanical properties of 3D-printed poly-ε-caprolactone (PCL) scaffolds with varying porosities were determined to assess overall material
Laura K Zamurs et al.
The Journal of biological chemistry, 290(7), 4272-4281 (2014-12-24)
Bethlem myopathy and Ullrich congenital muscular dystrophy (UCMD) sit at opposite ends of a clinical spectrum caused by mutations in the extracellular matrix protein collagen VI. Bethlem myopathy is relatively mild, and patients remain ambulant in adulthood while many UCMD
Russell J Butterfield et al.
PloS one, 12(12), e0189664-e0189664 (2017-12-16)
The collagen VI related muscular dystrophies (COL6-RD), Ullrich congenital muscular dystrophy (UCMD) and Bethlem myopathy (BM) are among the most common congenital muscular dystrophies and are characterized by distal joint laxity and a combination of distal and proximal joint contractures.
Laura Briñas et al.
Annals of neurology, 68(4), 511-520 (2010-10-27)
Mutations in the genes encoding the extracellular matrix protein collagen VI (ColVI) cause a spectrum of disorders with variable inheritance including Ullrich congenital muscular dystrophy, Bethlem myopathy, and intermediate phenotypes. We extensively characterized, at the clinical, cellular, and molecular levels
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