MAB3073
抗G蛋白Goα抗体，克隆2A
clone 2A, Chemicon®, from mouse
别名:
Anti-DEE17, Anti-G-ALPHA-o, Anti-GNAO, Anti-HG1G, Anti-HLA-DQB1, Anti-NEDIM
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
2A, monoclonal
Application:
western blot
Species reactivity:
rat, bovine, human, guinea pig, mouse
Citations:
58
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
抗G蛋白Goα抗体，克隆2A, clone 2A, Chemicon®, from mouse
Quality Level
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
2A, monoclonal
species reactivity
rat, bovine, human, guinea pig, mouse
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... GNAO1(2775)
Application
抗G蛋白Goα抗体，克隆2A是用于WB的抗G蛋白Goα的抗体。
研究子类别
GPCR，cAMP/cGMP&钙信号传导
GPCR，cAMP/cGMP&钙信号传导
研究类别
信号传导
信号传导
蛋白质印迹1:3000。
标记牛和大鼠膜中39-42 kDa的单个蛋白带。
最佳工作稀释度必须由最终用户进行确定。
标记牛和大鼠膜中39-42 kDa的单个蛋白带。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
Go-α。 与牛（100%）、人（70%）、大鼠（61%）和小鼠（54%）具有强反应性。 与豚鼠轻微反应（27%）。 与牛G-α-t，大鼠Go-α，大鼠Gi-α-1，Gi-α-2，大鼠Gi-α-3，牛Gs-α和鼠Go-α-A和Go-α-B相比，通过蛋白质印迹证实了特异性。比较了在细菌裂解物中表达的Go-α（Go-α-A和Go-α-B）的羧基末端剪接变体的反应性，发现它们是相等的。由于Go-α-A和Go-α-B与大鼠Go-α-1和人Go-α-2具有>95%的同源性，因此MAB3073也将检测这些G蛋白。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
之前的UniProt蛋白质标识符(protein identifier)P29777已被纳入P09471。详情参见UniProt蛋白质数据库。
Immunogen
通过Sternweis和Robishaw的方法纯化的牛脑Go-α（J.Biol.Chem.[1984]259，13806）。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
形式：纯化
纯化的免疫球蛋白。 液体，溶于0.02 M PBS、0.25 M NaCl、pH值7.6中，含有0.1%叠氮化钠作为防腐剂。
Preparation Note
自收到之日起，在 2-8° 以未稀释的等分试样可保存 6 个月。
在运输过程中，少量抗体有时会夹在产品瓶的密封中。 对于体积为200μl或更小的抗体，我们建议在小瓶的硬质表面上轻轻敲打，或在台式离心机中短暂离心小瓶以除去容器′盖中的所有液体。
在运输过程中，少量抗体有时会夹在产品瓶的密封中。 对于体积为200μl或更小的抗体，我们建议在小瓶的硬质表面上轻轻敲打，或在台式离心机中短暂离心小瓶以除去容器′盖中的所有液体。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Pavitra S Ramachandran et al.
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Within the next decade, we will see many gene therapy clinical trials for eye diseases, which may lead to treatments for thousands of visually impaired people around the world. To target retinal diseases that affect specific cell types, several recombinant
Michiel van Wyk et al.
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Recent studies have demonstrated the safety and efficacy of ocular gene therapy based on adeno-associated viral vectors (AAVs). Accordingly, a surge in promising new gene therapies is entering clinical trials, including the first optogenetic therapy for vision restoration. To date
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Current biology : CB, 27(17), 2600-2609 (2017-08-29)
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