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MAB2624

Sigma-Aldrich

抗内皮粘蛋白抗体,克隆V.5C7

clone V.5C7, from rat

别名:

Endomucin-2, Gastric cancer antigen Ga34, Mucin-14, MUC-14, Endomucin-1/2

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rat

质量水平

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

V.5C7, monoclonal

种属反应性

mouse

技术

flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

同位素/亚型

IgG1κ

NCBI登记号

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

mouse ... Emcn(59308)

一般描述

内啡肽是一种内皮唾液分泌蛋白,属于一类糖蛋白,特征是高水平的o -糖解离和丰富的唾液酸。它可以抑制黏附聚集并阻碍细胞外基质和细胞的相互作用。在肾、心、脑、肝、肺、脾和胸腺中表达最多。内啡肽只存在于内皮细胞中。

免疫原

小鼠内皮粘蛋白细胞

应用

免疫沉淀分析: 一个先前批次已被独立实验室用于bEND细胞裂解物的IP(Morgan, 1999)。

免疫组织化学分析: 一个先前批次已被独立实验室用于小鼠舌头、心脏、子宫、大脑和小肠冷冻和石蜡包埋组织切片的免疫组织化学染色(Morgan, 1999)。

流式细胞术分析: 一个先前批次已被独立实验室用于转染COS-7细胞的FC(Morgan, 1999)。
抗内皮粘蛋白抗体,克隆V.5C7可检测内皮粘蛋白水平,已发布,经验证可用于WB、IP、IH、FC。
研究子类别
细胞器&细胞标志物

粘附(CAM)

质量

已通过蛋白质印迹在小鼠内皮瘤细胞系中进行了评估。

蛋白质印迹分析: 0.0025 µg/mL该抗体可在10 µg的bEND3细胞裂解液中检测到内皮粘蛋白。

目标描述

观察值为~ 75kDa

外形

形式:纯化

分析说明

对照
bEND3细胞裂解液

其他说明

浓度:请参考批次特异性浓缩物的检验报告。

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WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Meghan Grojean et al.
Journal of cellular and molecular medicine, 25(11), 4950-4961 (2021-05-04)
Elevated expression of multiple growth factors and receptors including c-Met and VEGFR has been reported in gastric adenocarcinoma (GAC) and thus provides a potentially useful therapeutic target. The therapeutic efficacy of foretinib, a c-Met/VEGFR2 inhibitor, was determined in combination with
Enhancing gastric cancer conventional chemotherapy effects by triple angiokinase inhibitor nintedanib in preclinical models.
Awasthi, et al.
Frontiers in Oncology, 13, 1145999-1145999 (2023)
Kate Crawford et al.
Cancer biology & therapy, 22(10-12), 619-629 (2021-12-10)
Standard chemotherapy regimens for gastric adenocarcinoma (GAC) have limited efficacy and considerable toxicity profiles. Nab-paclitaxel has shown promising antitumor benefits in previous GAC preclinical studies. Dovitinib inhibits members of the receptor tyrosine kinase family including FGFR, VEGFR and PDGFR, and
Kristina Y Aguilera et al.
Bio-protocol, 4(19) (2014-10-05)
Therapy-induced hypoxia drives changes in the tumor microenvironment that contribute to the poor response to therapy. Hypoxia is capable of driving the expression and/or activation of specific signaling cascades (e.g., c-Met, Axl, CTGF), the recruitment of tumor promoting immune cells
Nelida Olave et al.
American journal of physiology. Lung cellular and molecular physiology, 315(4), L535-L544 (2018-06-29)
Cyclooxygenase-2 (COX-2/PTGS2) mediates hyperoxia-induced impairment of lung development in newborn animals and is increased in the lungs of human infants with bronchopulmonary dysplasia (BPD). COX-2 catalyzes the production of cytoprotective prostaglandins, such as prostacyclin (PGI2), as well as proinflammatory mediators

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